Ketonemia, Ketosis, Mental Fatigue
Conditions
Keywords
Ketone supplements, Cognitive function, Exercise
Brief summary
15 healthy trained males will volunteer to participate in this study. there will be 2 treatments: Ketone esters supplementation and iso-caloric carbohydrate. The purpose of this study is to evaluate the effect of ketone esters on cognitive function during exercise after induced mental fatigue
Detailed description
mental fatigue is often seen in sports of moderate to long duration. its onset is associated with detriments in cognitive function which leads to poor decision making and detriments in specific sport skills. Ketones can serve as a powerful brain fuel source so they may have the potential to delay/ revert the onset of mental fatigue. in this experiment, we will induce mental fatigue in individuals who will be performing 45 minutes of intermittent exercise right after. During exercise cognitive function will be measured under 2 condition, Ketone supplementation and placebo. The purpose of this study is to see if ketones can play a role in reverting that initial mental fatigue during exercise, compared to placebo.
Interventions
BEHAVIORALmental fatiguing task
a 30-minute computerized Stroop test will be used to induce mental fatigue before exercise intervention
BEHAVIORAL45 - minute simulated soccer game
an intermittent running protocol using intensities and speeds seen in soccer will be used to simulate the physiological demands of the sport
BEHAVIORALcognitive function
The Stroop test and a complex reaction time test will be used to assess cognitive function during exercise.
Sponsors
Western University, Canada
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Masking description
Participants and investigators will be blinded as an individual not involved in the project will assemble and distribute the treatment (drinks) according to a coding system that is kept confidential until the study is completed. Participants will complete the protocol twice and the treatment order will be systematically rotated to avoid any order effect. taste and texture of treatments will be matched and will be distribute in opaque bottles to keep participant blinded
Intervention model description
This will be a double blind repeated measures cross over study. There will be two treatments involved: Ketone esters supplements and iso-caloric carbohydrates (placebo). Participants will complete the protocol twice and the treatment order will be systematically rotated to avoid any order effect. Design of the study is composed of a mental fatiguing task, followed by a 45 minute simulated soccer game (second half). Cognitive function will be assessed during the 45 minutes of exercise. All participants will perform the protocol in a fed state (4 h after consumption of their last meal)
Eligibility
Sex/Gender
MALE
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* In order to be eligible to participate in this study you must be a healthy male or female recreationally active individual, 18-35 year old.
Exclusion criteria
* You will be excluded from this study if you: * Are not involved in regular exercise (at least 2x week) * Have symptoms or take medication for respiratory, cardiovascular, metabolic, neuromuscular disease * Use any medications with side effects of dizziness, lack of motor control, or slowed reaction time * Are taking part in another research study * For women, if you are pregnant or become pregnant during the study. * Have a history of concussion/head injuries. * Have an excessive alcohol intake (\>2 drinks/day) * Are consuming a ketogenic diet (for at least 2 weeks) * Are a smoker * \*\* Cannabis use is not a
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cognitive function | 30 minutes | participants will be doing the Stroop test and a complex reaction test during exercise. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Blood Ketones | 45 minutes | Ketones in blood will be measured using a ketone meter |
| Blood Glucose | 45 minutes | blood glucose will be measured using a glucometer |
| Blood Lactate | 45 minutes | blood lactate will be measured using a lactate meter |
Countries
Canada
Contacts
Primary ContactPeter WR Lemon, PhD
Backup ContactManuel Quinones, MSc
Outcome results
None listed