Covid19, Healthcare Worker
Conditions
Brief summary
Recent studies have shown that some individuals may be asymptomatic but continue to shed the COVID-19 virus. These individuals may represent a population that can unknowingly transmit the virus. Healthcare workers (HCW) may acquire COVID-19 from the community or from possibly infected patients. It is important to gather data with respect to this to further understand the prevalence of asymptomatic carriage in individuals who work in research facilities, offices and clinical areas of hospitals and research facilities/institutes since this has important implications for infection control, as well as staff and patient safety. The purpose of this study is to test whether a proportion of these individuals may be asymptomatic shedders of the COVID-19 virus.
Detailed description
Healthcare workers of participating institutions who agree to be participants will: * Fill out some information about participants into a database portal system. Participants will have the ability to check their COVID-19 test results via the portal. * Have nasopharyngeal (NP) swabs done for COVID-19 testing. This can be done about once a week for up to 8 weeks (about 1-8 swabs total). * Provide optional blood samples to look for COVID-19 specific antibodies and/or proteins at the time of enrollment and after 8 weeks. * Fill out questionnaires about participant exposures and travel history, occupation category, any symptoms in the past 21 days, whether they have provided any face-to-face care of a known COVID-19 positive patients in past 14 days or if participants have any children at home who are less than 12 years of age. * Fill out an optional questionnaire about their mental health * Be contacted by telephone if participants are tested positive, to determine whether participants have symptoms of COVID-19, and for the results of any follow-up COVID-19 testing that may have been done.
Interventions
DIAGNOSTIC_TESTOptional saliva sample (for validation)
Provide saliva sample anonymously.
DIAGNOSTIC_TESTNasopharyngeal swab
Nasopharyngeal swab for COVID-19
OTHERQuestionnaire collection (CITF)
Fill out questionnaires regarding exposures and travel history, occupation category, any symptoms in the past 21 days, any face-to-face care of a known COVID-19 positive patients in past 14 days or any children at home who are less than 12 years of age.
OTHEROptional blood collection
Provide blood samples to look for COVID-19 specific antibodies and/or proteins at the time of enrollment and after 8 weeks.
OTHEROptional questionnaire completion (mental health)
Fill out an optional mental health questionnaire.
DIAGNOSTIC_TESTNasal Swab (rapid antigen test)
Panbio nasal swab rapid antigen test
Sponsors
University Health Network, Toronto
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Individuals who work within a food production, healthcare, research or clinical organization. * Asymptomatic as per daily screening. * No contraindication to performing a NP swab.
Exclusion criteria
* Any individual with fever, respiratory or flu-like symptoms will not be eligible. Symptom positive individuals who were not picked up at entry screening will be referred to their Occupational Health. Specific symptoms include: * Fever, chills or headache * New or worsening cough * Shortness of breath, difficulty breathing, sore throat or difficulty swallowing * Runny nose or stuffy nose without another cause (e.g. allergies) * Nausea/vomiting, diarrhea, stomach pain * Decrease/loss of taste or smell * Unexplained fatigue, malaise, muscle aches * Eye pain or pink eye In addition to those symptoms listed above, individuals should also be screened for symptoms as per their institutional requirements. * Enrolled in a COVID-related interventional study (eg. Behavioural or drug study).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of healthcare workers who are asymptomatic while COVID-19 positive | 2 years | To determine whether asymptomatic individuals who work within a food production, healthcare, research or clinical organizationmay shed CoV during the pandemic. We hypothesize that a small proportion (\ 1-10%) of these asymptomatic individuals may be CoV+ either because they are in the incubation period prior to symptoms or remain asymptomatic for the duration of infection. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Prevalence of any COVID-19 variants of concern in asymptomatic workers | 2 years | To assess the prevalence of any COVID-19 variants of concern in asymptomatic workers. |
| Spread of any COVID-19 variants of concern in asymptomatic workers | 2 years | To help determine the validity of the Panbio COVID-19 Ag Rapid Test and the saliva sample COVID-19 test by conducting these tests alongside the NP swab test. |
Countries
Canada
Outcome results
None listed