Healthy, Stroke
Conditions
Brief summary
This is a proof-of-concept study with a prospective observational design, where the association between progressive levels of verticalization and cerebral blood flow velocity (Ultrasound) in subacute stroke patients and healthy subjects will be investigated.
Interventions
PROCEDUREVerticalization
Progressive levels of verticalization
Sponsors
University of Zurich
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* First-ever ischemic stroke in the territory of the middle cerebral artery (MCA) * ≤12 hours after mechanical thrombectomy * Conscious * Hemodynamically stable * 18 years or older * Informed consent of the patient and/ or legal representative
Exclusion criteria
* Verticalization not allowed according to treating physician * Known pre-stroke disease affecting cerebral blood flow * Temporal bone windows insufficient to enable ultrasound penetration * Intubation anticipated or occurred * Venous thromboembolism * Symptomatic intracranial hemorrhage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Blood flow velocity | within 12 hours post thrombectomy | Cerebral blood flow velocity measured with transcranial doppler ultrasound |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate | within 12 hours post thrombectomy | Number of contractions (beats) of the heart per minute |
| Blood pressure | within 12 hours post thrombectomy | Systolic and Diastolic pressure |
| Oxygen saturation | within 12 hours post thrombectomy | Relative measure of the concentration of oxygen in the blood |
| Impairment caused by a stroke | within 12 hours post thrombectomy | National Institutes of Health Stroke Scale - NIHSS (Maximum score 42 - higher scores mean a worse outcome) |
| Neurological status | within 12 hours post thrombectomy | Glasgow Coma Scale - GCS (Maximum score 15 - higher scores mean a better outcome) |
| Adverse events | within 12 hours post thrombectomy | headache, focal edema, seizures, hemorrhagic transformation |
Other
| Measure | Time frame | Description |
|---|---|---|
| Disability | 3 month post stroke | modified Rankin Scale - mRS (maximum score 6 - higher scores mean a worse outcome) |
| Health-related quality | 3 month post stroke | Patient-Reported Outcomes Measurement Information System® 29 |
| Independence in gait | 3 month post stroke | Functional Ambulation Categories (Maximum score 5 - higher scores mean a better outcome) |
| Perfusion imaging | within 24 hours post thrombectomy | Cerebral blood flow |
| Reperfusion after thrombectomy | within 12 hours post thrombectomy | modified Thrombolysis in Cerebral Infarction |
Countries
Switzerland
Contacts
Primary ContactJeremia Held, PhD
Outcome results
None listed