Acute Ischemic Stroke
Conditions
Brief summary
Adult patients who are diagnosed with an acute supratentorial ischemic stroke within 48 hrs of onset will be enrolled into the study. Participants will undergo both a CT Scan and PET scan within 7 days of onset. Participants will have the option to undergo a second PET scan with fluorodeoxyglucose (FDG).
Detailed description
Patients older than 18 years of age diagnosed with an acute supratentorial ischemic stroke within 48 hrs of symptom onset will be prospectively enrolled. Research imaging will be obtained before 7 days after symptom onset. The patient will receive the standardized treatment protocol at the hospital. Informed consent will be obtained from each patient or a substitute decision maker for each individual imaging study (CTP, Rb PET, and FDG PET). The patient will be given the option of undergoing the CTP imaging with the Rb PET only or both the Rb PET and FDG PET components.
Interventions
None listed
Sponsors
University of Alberta
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age: \>18 yo * Gender: male or female * Acute (within 7 days from symptom onset) Supratentorial Ischemic Stroke
Exclusion criteria
* 1\) Planned surgical intervention * 2\) Severely abnormal blood glucose level (will be excluded from FDG PET imaging) * 3\) Unable to undergo CTP or PET imaging (i.e. claustrophobia) * 4\) Pregnancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Compare PET brain perfusion imaging to CTP | through study completion, 1 year from start of recruitment | Imaging of CTP images with the Rb PET only or both the Rb PET and FDG PET with CTP imaging components to evaluate blood flow and metabolism mismatches. |
Countries
Canada
Contacts
PRINCIPAL_INVESTIGATORBrian Buck
Associate Professor
Outcome results
None listed