Diabetic Nephropathies
Conditions
Keywords
obesity, diabetic nephropathies, biomarkers, metabolites
Brief summary
Diabetic kidney disease is one of the most severe and frequent complications of diabetes. Few preclinical markers are available apart from plasma creatinine and microalbuminuria. These markers are imperfect (some patients with advanced renal disease do not have an increase in markers) and late. Therefor there is an uncovered need to identify complementary biomarkers. Magnetic Resonance Spectroscopy (MRS) is a Magnetic Resonance Imaging (MRI) technique that allows the physiology and biochemistry of human body tissues to be studied in a non-invasive and non-irradiating manner.
Interventions
DIAGNOSTIC_TESTMRI
MRI
Sponsors
Poitiers University Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
35 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Common to all 3 category * Male or female, * Age≥ 35 years, * Subject free, with legal protection guardianship or curatorship; * Enrollment in the French Social Security system; * Informed consent signed by the patient Obese patients * BMI \>30 kgm² ; * With no known diabetes; * estimated glomerular filtration rate (eGFR) \> 60 ml/min/1.73m² and urine albumin-creatinin ratio (ACR) \< 3 mg/g Type 2 diabetic patients without kidney disease \- eGFR \> 60 ml/min/1.73m² AND ACR \< 3 mg/g, Type 2 diabetic patients with diabetic kidney disease defined as eGFR 30 to 60 ml/min/1.73m² OR ACR \> 30 mg/mmol.
Exclusion criteria
Age \< 35 years History of kidney transplant Any contraindication to an MRI examination Legal protection, namely minors, persons deprived of their liberty by a judicial or administrative decision, persons residing in a health or social establishment, adults under legal protection and finally patients in emergency situations Pregnant or lactating women, women of childbearing age who do not have effective contraception
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Correlation between morphometric and functional and metabolic biomarker data obtained by magnetic resonance spectroscopy (MRS) in 3 different patient groups | 1 month |
Secondary
| Measure | Time frame |
|---|---|
| Association between MRS biomarkers and annual glomerural filtration rate slope calculated within 3 previous years | 3 years |
| Correlation between metabolic MRS biomarkers and urine and plasma metabolites quantification. | 1 month |
Countries
France
Outcome results
None listed