Obesity Hypoventilation Syndrome (OHS)
Conditions
Keywords
Obstructive Sleep Apnea, Sleep Hypoventilation
Brief summary
This study focuses on a comprehensive examination of obese patients with sleep-related breathing disorders including patients with OSA, sleep hypoventilation and OHS. The aim of this study is to (1) evaluate characteristics of and differences between severity levels of obesity-related breathing disorders, (2) discuss pathophysiological variables associated with hypoventilation during sleep or at daytime and (3) find functional parameters indicating sleep hypoventilation.
Interventions
DIAGNOSTIC_TESTSleep Study
Full-night attended in-lab polysomnography with accompanying transcutaneous capnometry
DIAGNOSTIC_TESTPulmonary Function Test
Bodyplethysmographic assessment
DIAGNOSTIC_TESTHypercapnic ventilatory response
Measurement of hypercapnic ventilatory response based on the method described by Read in 1967, using a rebreathing bag
DIAGNOSTIC_TESTCardiopulmonary Exercise Test
Symptom-limited cardiopulmonary exercise test with a ramp protocol according to the ATS/ACCP and ERS recommendations
Sponsors
Philips Respironics
Wissenschaftliches Institut Bethanien e.V
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Age ≥18 years * BMI ≥ 30 kg/m² * Indication for sleep lab admission or indication for BiLevel or non-invasive ventilation therapy initiation due to existing hypoventilation/OHS
Exclusion criteria
* Age \<18 years * Pregnancy, Lactation * Any medical, psychological or other condition impairing the patient's ability to provide informed consent. * Missing informed consent * Participation in another clinical study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypercapnic ventilatory response | Within 48 hours of sleep lab admission |
Countries
Germany
Outcome results
None listed