Specific Methylation Profiles in HNSCC

Validation of Specific Methylation Profiles Ind Head and Neck Cancer - a Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04567056

Enrollment

300

Registered

2020-09-28

Start date

2020-09-16

Completion date

2026-06-01

Last updated

2025-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Head and Neck Squamous Cell Carcinoma

Keywords

Head and neck cancer, Squamous Cell carcinoma, Methylation, DNA

Brief summary

In the study, N-20190047, the investigators aim to define specific methylation patterns in a group of patients with head and neck squamous cell carcinomas. With this study the investigators aim to validate these findings in a larger cohort.

Interventions

DIAGNOSTIC_TESTBlood sample

A separate blood sample will be taken for methylation-analyses

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Cancer group: Inclusion Criteria: * Written informed consent * Verified head and neck squamous cell carcinoma

Exclusion criteria

* Other active cancer * Uncontrolled comorbidity * Unable to give informed consent Control group: Inclusion Criteria: * Written informed consent * Normal ENT-examination

Design outcomes

Primary

Measure	Time frame	Description
Diagnostic accuracy	At diagnosis	How accurate can the methylation profiles diagnose the head and neck squamous cell carcinoma

Countries

Denmark

Contacts

Primary ContactChristian Danstrup, M.D.

csd@rn.dk+45 23800598

Backup ContactMichael Gaihede, Professor

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026