Covid19, Hypoxemia, Hypoxemic Respiratory Failure
Conditions
Keywords
O2matic, Closed-loop
Brief summary
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval.
Detailed description
Patients with coronavirus disease (COVID-19) and pneumonitis often have hypoxemic respiratory failure and a need of supplementary oxygen. Guidelines recommend controlled oxygen, for most patients with a recommended interval of SpO2 between 92 and 96 %. We aimed to determine if closed-loop control of oxygen was feasible in patients with COVID-19 and could maintain SpO2 in the specified interval. Patients were prospectively enrolled in an observational study on a medical ward dedicated to patients with COVID-19. Closed-loop controlled oxygen was delivered by O2matic® which can deliver 0-15 liters/min and adjusts flow every second based on 15 seconds averaging of SpO2 measured by pulse oximetry. Lung function parameters were measured at admission.
Interventions
DEVICEClosed-loop control of oxygen supplementation by O2matic
Closed-loop control of oxygen supplementation to achieve a target SpO2 of 92 - 96 %
Sponsors
Innovation Fund Denmark
Hvidovre University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 18 years * Positive COVID-19 PCR analysis in pharyngeal swab or in tracheal secretion * Need oxygen supply to maintain SpO2 ≥ 92 % * Able to comply with continuous measurement of SpO2 by pulse oximetry.
Exclusion criteria
* Need of oxygen supply \> 10 liters/min at admission
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Time in SpO2 target | 1 week | Time in SpO2 target of 92-96 % |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time with SpO2 not more than 2 % outside target | 1 week | Time with SpO2 not more than 2 % outside target |
| Time with SpO2 more than 2 % outside target | 1 week | Time with SpO2 more than 2 % outside target |
| Time with SpO2 < 85 % | 1 week | Time with SpO2 \< 85 % |
Countries
Denmark
Outcome results
None listed