Critically Illness
Conditions
Brief summary
The purpose of this study is to assess the efficacy of Heated Humidified High-Flow Nasal Cannula compared with noninvasive positive-pressure ventilation in the prevention of extubation failure in patients with prolonged mechanical ventilation.
Detailed description
There have been many clinical trials comparing the role of Heated Humidified High-Flow Nasal Cannula or Noninvasive positive pressure ventilation in the prevention of extubation failure. These review all have similar results summarized here: Compared with Noninvasive positive pressure ventilation, Heated Humidified High-Flow Nasal Cannula provides better patient comfort, fewer oxygen desaturation episodes, lower likelihood of interface displacement, and, lower reintubation rate than Noninvasive positive pressure ventilation. However, most of these clinical trials focused on participants experiencing acute respiratory failure. Investigators of this study want to find something difference between oh these two groups.
Interventions
Participants using of invasive ventilator more than 14 days, maybe considered transferred to the Respiratory Care Center(RCC), participants enrolled to this study and also written informed consent from participants or their family; After extubation, the difficult weaning patients were allocated to two treatment groups, and randomly assigned to Heated Humidified High-Flow Nasal Cannula or Noninvasive Ventilation devices.
Sponsors
Fu Jen Catholic University
Shin Kong Wu Ho-Su Memorial Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
20 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: Over 20 years of age * the requirement of at least six hours of mechanical ventilation per day for at least 14 consecutive days
Exclusion criteria
* Pregnancy * Status post tracheostomy * Neuromuscular diseases * Signed do not resuscitate order * Unplanned extubation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Re-intubation rate | within 72 hours of extubation | Any placement of an endotracheal tube for any indication within 72 hours of extubation, censored at the first of hospital discharge or 72 hours after extubation. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Mortality rate | up to 3 months | Mortality rate, or death rate is a measure of the number of deaths |
Outcome results
None listed