Fuchs Dystrophy
Conditions
Brief summary
This study is being done to discover if there is a link between estrogen exposure and the severity of Fuchs Endothelial Corneal Disease. We are trying to understand if the decrease in estrogen levels in post-menopausal women may be a reason why FECD is seen more often in women than men.
Interventions
OTHERThis is an observational study. There is no therapeutic intervention.
This is an observational study. There is no therapeutic intervention.
Sponsors
State University of New York at Buffalo
Study design
Observational model
OTHER
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
55 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Individuals with FECD grade 1-2/7 (mild) or 5-6/7 (severe) in one or both eyes 2. Age ≥ 55 3. Phakic and pseudophakic individuals will be included. Pseudophakic patients must have evidence of routine cataract surgery (posterior chamber intraocular lens in-the-bag without clinical evidence of damage to any intraocular structures).
Exclusion criteria
1. Females are excluded if not post-menopause. 2. Pseudophakic patients with a history of complex cataract surgery or other intraocular surgery (e.g. have an anterior chamber lens, sulcus lens, or poorly positioned posterior chamber lens, aphakia, iris damage, glaucoma surgery) will be excluded due to risk of iatrogenic damage to the corneal endothelium.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Association Between Fuchs endothelial Corneal Dystophy Severity and Estrogen Exposure | 5 years | Difference in measures of estriadiol exposure between individuals with mild vs. severe FECD |
Countries
United States
Outcome results
None listed