Oral Contraceptive Use, Recovery
Conditions
Brief summary
There is still no one who has studied how oral contraceptive use affects recovery in trained women after repeated high-intensity workouts. Consequently, a well-controlled study is needed. The project is designed as a controlled cohort study, where 20 oral contraceptive users will be compared with 20 non-users. After initial preliminary examination and habituation to the test procedures, the subjects will start the intervention in week 2 of their menstrual cycle / active contraceptive pill cycle. Before and 3h, 24h and 48h after 3 intense strength training sessions performed 2 days in a row, blood samples will be taken, muscle soreness measured and performance tests performed. The day before the first training session and over the 4 trial days, the subjects will receive a standardized diet.
Interventions
PROCEDURETraining
Both groups will perform a standardized training protocol
Sponsors
University of Aarhus
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
We will compare the recovery in a group of oral contraceptive users to a group of women not using oral contraceptives
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI 18.5-30 * Regular training minimum. 4 times a week (1≤ times strength training, 1≤ times endurance training / interval training or interval-based sports. If the interest in participation is greater than necessary, we will prioritize people who perform strength training at least twice a week)
Exclusion criteria
* Irregular menstruation over the last 6 months (shorter than 24 days or longer than 35 days cycle) * Used birth control pills for less than 6 months * Non-birth control pill users must not have used birth control pills, IUDs, birth control pills, or mini- pills for a maximum of 1 month during the last 6 months and not within the last 3 months up to the trial. . * Injuries / pain in the lower body, which prevents participation in intense strength training * Medication consumption that may affect protein metabolism and inflammatory parameters. * Diabetes * Smoking * Unstable weight / major weight loss (weight fluctuations of more than 5 kg in the last six months) * Eating disorder * Pregnancy * Cannot read or understand Danish
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in maximal knee extensor strength and Rate of force development | Before, 3 hours , 24 hours and 48 hours after training | Measured in a Humac Norm dynamometer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Wingate performance | Before, 3 hours , 24 hours and 48 hours after training. | Peak power and average power |
| Changes in Yoyo-intermittent recovery 1 performance | Before, and 48 hours after training. | total length covered in the yo-yo test |
| Changes in Leg press performance | Before, 3 hours , 24 hours and 48 hours after training. | Total reps performed at 80% of 1RM |
| Changes in Jumping performance | Before, 3 hours , 24 hours and 48 hours after training. | Jump height |
| Differences in knee laxity | Baseline | Measured with a Lachmeter |
| Changes in muscle soreness (VAS-score) | Before, 3 hours , 24 hours and 48 hours after training | Subjects will raise and sit on a chair and immediately after answer a VAS-score (100mm line, from worst pain ever, to no pain at all.) |
| Blood analysis: Sex hormones, cortisol, inflammatory markers and markers of muscle damage | Before, 3 hours , 24 hours and 48 hours after training | estradiol |
| Changes training volume | Before, 3 hours , 24 hours and 48 hours after training. | total volume performed during training (i.e set x reps x working weight) |
Countries
Denmark
Outcome results
None listed