ILD, IPF, Pulmonary Fibrosis
Conditions
Brief summary
This study plans to learn more about pulmonary fibrosis and how it develops. We want to determine if the disease can be detected early, before the lung is permanently scarred. This study will enroll participants who are not currently diagnosed with pulmonary fibrosis, but who have family members with pulmonary fibrosis. Because there is an increased risk within affected families, this cohort will allow us to learn how pulmonary fibrosis develops, and how the lungs change over time.
Interventions
OTHERSample collection
Blood, Urine, Nail, Hair, Saliva, optional Stool
OTHERQuestionnaires
SF-36, Food Frequency, Pulmonary Fibrosis Study questionnaire, COVID questionnaire
RADIATIONHigh resolution CT scan of the chest
Upon enrollment, all participants will undergo single prone volumetric thoracic chest CT scan. This will be performed at full inspiration using a 64-slice CT scanner.
DIAGNOSTIC_TESTPulmonary Function Test
All recruited participants will undergo a pre-bronchodilator spirometry test and a lung diffusion capacity test, both in accordance with ATS guidelines. Exercise capacity (maximum physical exertion) will be assessed by performing a 6-minute walk test, also according to ATS guidelines.
Sponsors
Mayo Clinic
University of California, Los Angeles
University of Texas
University of Pennsylvania
University of Colorado, Denver
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Unaffected first degree relative from Familial Interstitial Pneumonia families (two or more family members with IIP) * Age at least 40 years old and younger than 75 years old
Exclusion criteria
* Diagnosed with known (physician-diagnosed) pulmonary fibrosis prior to informed consent * Other genetic diseases associated with interstitial lung disease * Pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Screen all subjects for early Idiopathic Pulmonary Fibrosis (IPF) with High Resolution CT Scan of the Chest | Baseline | All subjects will be screened with a high resolution CT scan to identify early signs of lung fibrosis. CT scans will be evaluated by study radiologists. |
Countries
United States
Outcome results
None listed