The Relationship Between Oral Vitamin A Administration and the Incidence of BPD in Preterm Infants Born Before Week 29 of Pregnancy
Conditions
Brief summary
Chronic bronchopulmonary dysplasia (BPD) is a very common complication in preterm infants born at a young gestational age, and is a serious disease that impairs respiratory long-term outcome and is associated with higher-frequency neurodevelopmental injury. Lowering the incidence of BPD may improve the health of the preterm babies and neurodevelopmental delay of preterm infants.Vitamin A deficiency may be one of the factors associated with the development of BPD in preterm infants. According to the literature, oral vitamin A administration can lower the incidence of BPD. In our study we plan to give 5000 units of retinol / dose / day, every day for 28 days.
Interventions
DIETARY_SUPPLEMENTOral Vitamin A
Oral administration of 5000 EU of Vitamin A during first 28 days of life
Sponsors
Sheba Medical Center
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Caregiver, Investigator)
Eligibility
Sex/Gender
ALL
Age
2 Days to 5 Days
Healthy volunteers
No
Inclusion criteria
* Premature babies under 29 weeks, at any birth weight * A preterm baby is less than 4 days to life
Exclusion criteria
* Major congenital malformations * Known chromosomal disorders
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of BPD at 28 days | 28 days of life | Chronic pulmonary desease of prematue babies |
| Incidence of mortality at 28 days | 28 days of life | Death before 28 days of life |
Contacts
Primary ContactLeah Leibovitch, MD
Backup ContactLiudmila Lo Schiavo Winer, MD
Outcome results
None listed