Bipolar Disorder, Bipolar I Disorder, Bipolar II Disorder
Conditions
Keywords
bipolar disorder, emotion, cognition, stroop, proactive emotional processing
Brief summary
The main objective of this project is to identify behavioral specificities of the proactive emotional brain among bipolar patients, compared to healthy subjects. These could contribute to some of the emotional processing biases that can be observed in these patients. To achieve this goal, two behavioral tasks will be administer (emotional stroop and emotional stimuli categorization task) to bipolar patients and control subjects, and their performances will be compared.
Detailed description
This is a case-control non-interventional study comparing bipolar patients to matched healthy controls during one assessment visit at the University Hospital of Grenoble. The experimentation phase takes place in three stages: first, the experimenter collects demographic data (age and level of study, lack of medical history and treatments that may interfere with the task). For bipolar subjects, it also collects the type of bipolarity, the type and date of the last episode, the age of the onset of the disease and the treatment. Secondly, the subject performs a classic Stroop task lasting 3 to 5 minutes, including instructions. Finally, the subject performs the two main tasks: the emotional Stroop task lasting about 20 minutes and then the task of emotional stimuli categorization lasting about 15 minutes.
Interventions
BEHAVIORALEmotional Stroop Task
Classic Stroop task The subject names one of the 3 colors of the crosses on a sheet.Then, the subject must read the words written on the sheet for 45 seconds.These are the words: RED, BLUE and GREEN, written in black color. The subject must name the color of the word. Emotional Stroop task This is a computed task in which the patient is asked to answer both as accurately and as quickly as possible. The target stimulus is an emotional face of joy or anger, surmounted by the word joy or anger.The subject must respond using the arrow corresponding to the face he sees. A training phase is offered to the subject. 3 / Categorization task For each trial the participant will visualize a short emotional film or not. Then, the participant will have to choose, the emotion corresponding to what he just saw. A training period is offered too.
Sponsors
University Hospital, Grenoble
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Right-handed * Francophones * Bipolar disorder diagnosis (for patients) according to DSM-5 / CIM-10 criteria * Affiliation to the French social security insurance
Exclusion criteria
* uncorrected perceptual disturbance * psychiatric disorders other than bipolarity as the main psychiatric disorder or a condition which may affect the tasks proposed for the patients' group * subject under legal protection * subject deprived of freedoms by a judicial or administrative decision * drug abuse less than 12 hours before the assessment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| performances at the emotional Stroop task | day1 | percentage of correct answers ( in %), reaction time ( in seconds) and inverse efficiency score ( N.A) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sensitivity to interference during Stroop tasks | day1 | -reaction time (in seconds) in the different conditions of the task (reading in the congruent condition, interference during the incongruent condition) |
| Effect of mood state (depressive state) on behavioral tasks' performances | day 1 | assessment of the impact of mood scales (MADRS) scores on behavioral tasks performances |
| Effect of mood state (hypo/manic state) on behavioral tasks' performances | day 1 | assessment of the impact of mood scales (YMRS) scores on behavioral tasks performances |
Countries
France
Outcome results
None listed