Transcranial Alternating Current Stimulation
Conditions
Brief summary
By analyzing the SEEG recordings, we explore the range of cortical functional responses to strings of 77.5Hz stimulations delivered by tACS,
Interventions
DEVICEtACS
tACS would be performed to epilepsy patients who have already received implantation of the SEEG electrodes
Sponsors
Xuanwu Hospital, Beijing
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
14 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* All epileptic patients that would receive the implantation of SEEG electrodes, regardless of the seizure locations; * There was no metal implantation before; * Eligible for MRI examination; * No other lesional neurological disorders; * Could be well informed by the study protocols.
Exclusion criteria
* Suffered from any other mental illnesses prior to the enrollment; * Those suffering from the serious or unstable organic diseases; * Pregnant or lactation women, and those who have a plan of pregnant; * Patients with central nervous system tumors, acute brain injury or infection; * Skin injured, or allergic to the exposure of the conductive gel; * Those with implanted devices; * Those who received modified electrical convulsive therapy, or TMS within the recent one month; * The score of item 3 (suicidal item) in HAMD-17 equal or greater than 3; * Enrolled in any other on going trials; * Other situations evaluated by the researchers as inappropriate to the enrollment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes of intracranial activities | Within 250 ms immediately after the stimulation. | The change of the power in a band of 0-200 HZ according to the intracranial EEG recording. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Frequency of the epileptic discharges | 50 minutes during the stimulation and 50 minutes of the interictal baseline before the intervention during the same hour of the day | To count the numbers of epileptic discharges within the same duration before and when tACS intervention. |
| Event related potential (ERP) | Baseline: 24 hours before the tACS intervention; Observation: Immediately after the end of the tACS intervention. | ERP related to cognitive tasks before and immediately after the tACS intervention |
Contacts
Primary ContactP.H. Wei
Outcome results
None listed