Microvascular Coronary Artery Disease
Conditions
Brief summary
The important evidence of coronary microcirculation for the management of patients with coronary artery disease is only increasing. Thus, in recent years, a number of studies have shown that the demonstration of coronary microvascular disease (CMVD) contributes to cardiovascular morbidity and mortality increases independently of epicardial damage. This has been shown in stable coronary artery disease with screening for CMVD when there is no significant epicardial involvement and allowing the implementation of an adapted treatment then reducing the symptoms and improving the quality of life of our patients. (1). The prognostic nature of CMVD has also been identified in stable disease after coronary angioplasty (2) but also in patients with infarcts reperfused by coronary angioplasty (3). The complete exploration of the epicardial and microvascular coronary vascularization is grouped under the name of the subspecialty: coronary physiology. Thus, an internationally recognized algorithm for exploring coronary physiology has been published (4). However, this algorithm is still little followed. The PRINCIPE registry aims to assess the prevalence of CMVD with the use of a standardized algorithm for exploring coronary physiology by coronary angiography in our center in current practice.
Interventions
None listed
Sponsors
University Hospital, Grenoble
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Male or female patients over 18 years of age * Having a coronary angiography * Presenting in pain or having performed a positive ischemia test * Affiliated with social security * Non-opposition to participation
Exclusion criteria
* Adult patient protected by law (article L1121-8) * Person deprived of liberty (article L1121-8) * Pregnant woman
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of CMVD defined by microcirculatory resistance index (IMR) > 25 | At inclusion |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between coronary physiology parameters and imaging data | At inclusion | Coronary angiography and coronary physiology parameters:% of epicardial stenosis, FFR, CFR, IMR |
| Assessment of the symptoms of angina pectoris | 12 months | Brief angina questionnaire |
| Prevalence of macro and microvascular angina | At inclusion | Macro and microvascular angina rate according to international angiographic diagnostic criteria |
| Evaluate medical consumption | 12 months | Number of medical consultation |
| Evaluation of serious cardiovascular event rate | 12 months | Cardiovascular event |
| Compare the rate of peri-procedural myocardial distress | At inclusion | Post PCI troponin rate |
Countries
France
Contacts
Primary ContactGilles Barone Rochette, MD PhD
Backup ContactClemence Charlon, MSc
Outcome results
None listed