Epilepsy
Conditions
Keywords
epilepsy, biomarker, access to care, quality of care, seizure
Brief summary
PREDICT is an observational study following adults with an unprovoked seizure or epilepsy in the health care region of western Sweden. The objective is to identify biomarkers and/or genetic predisposition of relevance for diagnosis and/or treatment of epilepsy and study the long-term prognosis and consequences of epilepsy.
Detailed description
Adults over 18 years of age, with an unprovoked seizure in the last year or epilepsy, resident in the health care region of western Sweden (VGR) at the time of inclusion. Baseline data and outcome variables are collected from several patient registries: the electronic medical records system in the health care region VGR and Swedish National Registers of healthcare, income, and employment managed by The National Board of Health and Welfare or Statistics Sweden, both of which are government agencies.
Interventions
OTHERSeizure status
We will collect information on first seizure ever, last seizure ever, number of seizure in last two months.
DIAGNOSTIC_TESTTests
We will collect results from imaging, electroencephalogram, and laboratory tests.
OTHEREpilepsy
We will collect information on risk factors of epilepsy, cause of epilepsy, epilepsy type/syndrome, medications tried, if the epilepsy is drug resistent, side effects of antiepileptic drugs.
OTHERDemographics and psychosocial
We will collect information on age, sex, date of death if applicable, marital status, education level, income type, driving status, employment, benefits, sick leave, number of household members.
OTHERHealth care
We will collect information on received health care; visit dates, caregiver, dispensation dates of antiepileptic drugs
Sponsors
Sahlgrenska University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Over 18 years of age * An unprovoked seizure within the last year or a diagnosis of epilepsy according to the current International League Against Epilepsy definition (epilepsy with seizure in the last ten or antiepileptic drug treatment in the last five years)
Exclusion criteria
* Expected survival less than two years * Inability to give informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| epilepsy | baseline and years 1,2,3,4,5,6,7,8,9,10 | more than one seizure after first seizure |
| seizure status | baseline and years 1,2,3,4,5,6,7,8,9,10 | the number of seizures in last two months and overall |
| drug resistant epilepsy | baseline and years 1,2,3,4,5,6,7,8,9,10 | epilepsy that has not responded to two antiepileptic drugs |
| severe side effects of antiepileptic drug | baseline and years 1,2,3,4,5,6,7,8,9,10 | — |
| psychosocial outcomes | baseline and years 1,2,3,4,5,6,7,8,9,10 | employment, marital status, income, sick leave |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| received health care | baseline and years 1,2,3,4,5,6,7,8,9,10 | the number of visits for epilepsy, missed appointments, time intervals between visits |
Countries
Sweden
Contacts
Primary ContactJohan Zelano, MD PhD
Outcome results
None listed