Evaluation of the Threshold for the Interpretation of the Results of a Method for the Blood Determination of Phosphatidyléthanol

Status

Withdrawn

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04557631

Acronym

PETHOXICO

Enrollment

Registered

2020-09-21

Start date

2021-09-01

Completion date

2021-12-01

Last updated

2026-05-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alcohol Abuse

Brief summary

For an analytical validation of the method for the determination of blood hosphatidylethathanol, it is necessary to: * to compare the results of chronic and excessive ethanol patients with the cut-off proposed in the literature. * Also assess the stability of phosphatidylethanol in total blood collected, and in blotted dried blood stains (DBS), depending on temperature (ambient temperature and +4°C)

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Person with alcohol consumption ≥ 40g/day (women) and ≥ 60g/day (men) according to WHO criteria * Person hospitalized for a hospital withdrawal in the addiction service of Lille's hospital, without other distinctions.

Exclusion criteria

* Patient opposing the use of their personal data in the study * Patient subject to protective measures (guardianship or curatorship) * Person deprived of liberty

Design outcomes

Primary

Measure	Time frame
Frequency of patients with a Peth concentration greater than 200 µg/L	at the end of study (at 6 months)

Secondary

Measure	Time frame	Description
the concentration of Peth in blood in ambiant temperature	between T0 and 96h and the end of study (at 6 months)	descrease expressed as a percentage of the initial concentration, in the primary blood tube (citrate tube) and stored at room temperature,
the concentration of Peth in blood at 4°C	between T0 and 96h and the end of study (at 6 months)	ecrease expressed as a percentage of the initial concentration, in the primary blood tube (citrate tube) and at 4°C.
the concentration of Peth in blood in DBS	between T0 and 4 weeks and the end of study (at 6 months)	decrease expressed as a percentage of the initial concentration, in the Dried Blood Spot (DBS)

Contacts

PRINCIPAL_INVESTIGATOROlivier COTTENCIN, MD,PhD

University Hospital, Lille

Outcome results