Adherence, Obstructive Sleep Apnea
Conditions
Keywords
apnoea, effort based decision making, rehabilitation, adherence
Brief summary
Obstructive sleep apnoea is the most common sleep disorder in general population, and is often associated with cognitive deficit, mood disorders, hypertension, diabetes mellitus, excessive daytime somnolence, nicturia and an increased cardiovascular and metabolic risk. The gold standard of treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. The aim of our study is to investigate the effort based-decision making in patients with OSA, pre and post CPAP treatment, as a possible cause of poor adherence.
Detailed description
Obstructive sleep apnea is a very common disease in general population (24% males; 9% females), characterized by frequent partial or total upper-airway collapse, intermittent hypoxia, arousal from sleep, change in blood pressure, excessive daytime sleepiness, cardiovascular and metabolic diseases, psychological and cognitive consequences. The gold standard treatment is Continuous Positive Airway Pressure (CPAP), but the adherence is often poor. Poor therapy adherence might be partially explained by executive deficits, decreasing the ability to plan and pursue longsighted behaviors entailing immediate costs/efforts. We investigate the cognitive function, in particular effort based-decision making and the relationship with excessive daytime somnolence and other cognitive function in a group of OSA patients and in control group. We assess cognitive function in OSA patients at the diagnosis moment and after six months of CPAP use.
Interventions
Treatment of Obstructive sleep apnoea syndrome with CPAP
Sponsors
Istituto Universitario di Studi Superiori Pavia
Istituti Clinici Scientifici Maugeri SpA
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age ≥ 18 * AHI±15
Exclusion criteria
* BMI ≥ 35 Kg/m2 * MMSE \<24 * Complex sleep apnoea * Sleep disorder * Psychiatric disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Efforth decision making | Change will be assesd before starting CPAPT and after six months of CPAP treatment | Will be assesses with Rapid Serial Visual Presentation (RSVP) |
| Memory | Change will be assesd before starting CPAP and after six months of CPAP treatment | Short and Long-term memory will be assessed with Digit span and California verbal learning test |
| Executive Function | Change will be assesd before starting CPAPT and after six months of CPAP treatment | attentional and executive functioning will be assessed with Test of Attentional Performance (TAP) |
| Planning | Change will be assesd before starting CPAPT and after six months of CPAP treatment | Planning will be assessed with Tower of London |
| Response inhibition | Change will be assesd before starting CPAPT and after six months of CPAP treatment | Will be assessed with Test Go-nogo |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect of CPAP treatment on memory | After six month of CPAP use | Administration of Digit span and California verbal Learning test |
| Effect of CPAP treatment on executive function | After six month of CPAP use | Administration of Test attentional Performance |
| Effect of CPAP on planning | After six month of CPAP use | Adimnistration of Tower of London Test |
| Effect of CPAP on Response inhibition | After six month of CPAP use | administration of go no go Test |
| Effect of CPAP on effort decision making | After six month of CPAP use | Administration of Rapid Serial Visual Presentation (RSVP) test |
Countries
Italy
Contacts
Primary ContactNicola Canessa, PhD
Outcome results
None listed