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Brief Informational Intervention for COVID-19 Misinformation Prophylaxis

Brief Informational Intervention for COVID-19 Misinformation Prophylaxis

Status
Completed
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT04557241
Enrollment
1017
Registered
2020-09-21
Start date
2020-01-14
Completion date
2021-01-31
Last updated
2021-02-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID19 Behavioral Prophylaxis

Keywords

misinformation, trust, prevention

Brief summary

As the coronavirus disease 2019 (COVID-19) pandemic has continued to affect life in the United States, the important role of non-pharmaceutical preventive behaviors (such as wearing a face mask) in reducing harm has become clear. In parallel to the pandemic, researchers have observed an infodemic of misinformed or inconsistent narratives about COVID-19. There is growing evidence that misinformed COVID-19 narratives are associated with a wide variety of undesirable behavior (e.g., burning down cell towers). Further, individuals' adherence to recommended COVID-19 preventive guidelines has been inconsistent, and such mandates have engendered opposition and controversy. Recent research suggests the possibility that trust in science and scientists may be an important thread to weave throughout these seemingly disparate components of the modern public health landscape. Thus, this paper describes the protocol for a randomized trial of a brief, digital intervention to increase trust in science. The objective of this trial is to examine if exposure to a curated infographic can increase trust in science, reduce believability of misinformed narratives, and increase likelihood to engage in preventive behaviors.

Detailed description

The investigators propose a single-stage, randomized, superiority trial with 2 parallel groups allocated with a 1:1 ratio. The comparator in this study will be a control (placebo) infographic that is completely unrelated to science (e.g., about cats), but that is developed using the same communication and graphical style. Subjects will be recruited using the Prolific data collection platform, which is one of two primary online crowdsourced research platforms (the other is Amazon's Mechanical Turk, or mTurk). To be included, participants must be identified by Prolific as part of a nationally-representative sample. Participants will also be required to be age 18 or older, and to reside in the United States. Individuals who decline to digitally sign the informed consent document will be excluded and replaced. Per recent best practice recommendations for crowdsourced digital research, attention checks and screens for bots and international users with virtual private networks to mimic US IP addresses will be embedded within the instruments, and failure of more than one attention check, or any bot/location check will result in subject exclusion and replacement. Replacements will be drawn in such a way as to preserve the representativeness of the sample. Missing data will be addressed using either full information maximum likelihood or Markov Chain Monte Carlo multiple imputation strategies. When there is a violation of missing at random (which is unlikely) in preliminary analyses, the investigators will incorporate strategies representing the missingness. The researchers will further explore data quality in terms of outliers, measurement error, non-normality, and variance heterogeneity. Robust methods of analysis (e.g., Huber-White robust standard errors) will be used, as appropriate. For all multi-item measures, reliability will be evaluated prior to computation of the variable.

Interventions

BEHAVIORALBrief informational infographic

The primary intervention in this study will be an infographic that is designed to build trust in the scientific process. Infographics are preferable to narratives or text because they center visuals as part of the storytelling process and facilitate cognitive information processing, knowledge absorption, and enhanced persuasion. The study's infographic design will follow best practices in health communication. The message will be simple and jargon free. Visuals will include individuals (scientists), charts, text, and numbers. Attention will be paid to images, color, frames, representation, and composition (e.g., how the elements in the infographic are organized to show their relationship to each other).

BEHAVIORALPlacebo control (non-behavioral infographic)

The comparator in this study will be a control (placebo) infographic that is completely unrelated to science (e.g., about cats), but that is developed using the same communication and graphical style.

Sponsors

Indiana Clinical and Translational Sciences Institute
CollaboratorOTHER
Indiana University
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Outcomes Assessor)

Masking description

Although this is, in practice, a double-blind study since participants will be unaware that they are randomized and all study mechanics will be processed by computer, analysts will not be blinded to the meaning of the assignment variable. However, two independent consultant analysts have been retained to verify all results and subsequent interpretation.

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes

Inclusion criteria

* To be included, participants must be identified by Prolific as part of a nationally-representative sample. Participants will also be required to be age 18 or older, and to reside in the United States.

Exclusion criteria

* Individuals who decline to digitally sign the informed consent document will be excluded and replaced. Per recent best practice recommendations for crowdsourced digital research, attention checks and screens for bots and international users with virtual private networks to mimic US internet protocol addresses will be embedded within the instruments, and failure of more than one attention check, or any bot/location check will result in subject exclusion and replacement.

Design outcomes

Primary

MeasureTime frameDescription
Change in trust in sciencePre-intervention and immediately post-intervention21-item scale developed by Nadelson et al \[1\] called the Trust in Science Inventory. It is scored from 1 to 5, where 1 indicates low trust and 5 indicates high trust.
Believability profilesImmediately post-interventionWill be computed using latent profile analysis of believability measures. These measures were developed and first used in our recent study of COVID-19 narratives \[2\]. Response options for these measures used well-established semantic differential responses for believability of different statements (e.g., as in Herzberg et al.) \[3\] ranging from \[1: Extremely unbelievable\] to \[7: Extremely believable\]. Exact measures used to generate profiles for this study will be available in the published protocol paper (to be submitted).
Preventive behavioral intentionsImmediately post-interventionA series of six questions based on the US Centers for Disease Control and Prevention's recommended COVID-19 preventive behaviors. \[4\] Questions will be written according to Azjen's guide to intention questionnaires \[5\].

Other

MeasureTime frameDescription
COVID-19 diagnosis (covariates 7 and 8)Immediately post-interventionTwo self report questions. The first asks whether the respondent has been diagnosed with COVID-19, and the second asks more broadly whether the respondent believes they have had COVID-19. Question wording will be per Bruine de Bruin (2020) \[7\].
Perceived severity of COVID-19 (covariate 9)Immediately post-interventionBased on the Health Belief Model as used in Yıldırıma & Gülerc \[8\].
Political orientation (covariate 1)Immediately post-interventionScale variable (0: Conservative to 10: Liberal) as in our prior work \[2, 6\]
Normative beliefs about friends' and family's COVID-19 behaviorsImmediately post-interventionSingle item from Chambon et al \[9\].
Self-efficacy to act regarding COVID-19Immediately post-interventionBased on the Health Belief Model as used in Yıldırıma & Gülerc \[8\].
Religious commitment (covariate 2)Immediately post-interventionScale variable (0: Low commitment to 10: High commitment) as in our prior work \[2, 6\]
Sociodemographics (covariates 3 through 6)Immediately post-interventionRace/ethnicity, gender, age, and education level using standardized questions

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 17, 2026