Non-stented Ureteroscopic Laser Lithotripsy for Ureteric Stones
Conditions
Keywords
Uretroscopic lithotripsy, non-stented, alpha1-blocker, LUTS, postoperative pain
Brief summary
To assess the efficacy of peri-operative alpha1 blockers on improving the success rate and decreasing complications of non-stented ureteroscopic laser lithotripsy for ureteric stones.
Detailed description
Objective: To assess the efficacy of peri-operative alpha1 blockers on improving the success rate and decreasing complications of non-stented ureteroscopic laser lithotripsy for ureteric stones. Patients and Methods: A randomized control trial was conducted at two high volume urological centers from September 2017 to December 2018. We enrolled 120 patients with lower ureteric stones. They were randomly divided into two groups. Group A had 58 patients who underwent non-stented ureteroscopy using Ho-YAG laser for stone disintegration and received alpha1-blockers for one week preoperatively and another two weeks postoperatively, while Group B had 62 patients who underwent non-stented ureteroscopy and laser and received placebo.
Interventions
To assess the efficacy of peri-operative alpha1 blockers on improving the success rate and decreasing complications of non-stented ureteroscopic laser lithotripsy for ureteric stones.
DRUGPlacebo
Placebo - control group
Sponsors
Ain Shams University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
patients were blinded to the type of intervention, as well as the data collector
Intervention model description
We enrolled 120 patients with lower ureteric stones. They were randomly divided into two groups. Group A had 58 patients who underwent non-stented ureteroscopy using Ho-YAG laser for stone disintegration and received alpha1-blockers for one week preoperatively and another two weeks postoperatively, while Group B had 62 patients who underwent non-stented ureteroscopy and laser and received placebo.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients with single lower ureteric stones of size range between 0.5 and 2 cm
Exclusion criteria
* Patients under the age of 18, pregnant women, or those with urinary tract infections, uncorrected bleeding disorders or coagulopathies, bilateral ureteric stones, single kidney, ureteral stricture, multiple ipsilateral ureteric stones were excluded from our study. Also, any patients who required ureteric stenting were excluded from our study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Need for dilatation | intraoperative assessment | ( to evaluate whether the ureteroscope will pass easily through the ureter if not , serial ureteric dilatation will be done and documented ) it is a yes or no evaluation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lower urinary tract symptoms LUTs | early postoperative period ( 2 weeks) | (frequency, urgency and dysuria) (Yes/NO) |
| Need for analgesia | first day postoperative | need for analgesics for postoperative pain according to the numeric rating scale (yes/no) |
| Time of operation (min) | intraoperative assessment | duration of the procedure in minutes |
| Fever | early postoperative (2 weeks) | elevated body temperature post operative in degree Celsius |
| hospital stay | from few hours up to 2 days postoperative | duration in hours |
| Gross Hematuria | first day postoperative | post operative hematuria (present or not ) |
Countries
Egypt
Outcome results
None listed