Cystic Fibrosis, Salt; Deficit (or Low)
Conditions
Brief summary
The results of the annual check-up will be collected to evaluate the best urinary marker for fractional sodium excretion and salt status will be correlated to clinical outcome measures.
Detailed description
Patients with cystic fibrosis need extra salt as they have increased losses through sweat. Current advices are to follow and supplement if needed, however the way to follow salt depletion is unclear. The best way is to calculate fractional salt excretion. This needs a simultaneous blood and urine sample for electrolytes and creatinin. Urinary surrogate markers have been validated on only 10 patients. At the annual check-up patients with cystic fibrosis receive these measurements. The investigators will collect the measurements and calculate fractional excretion and the possible surrogate markers on urine. Further this will be correlated to nutritional and pulmonary status and patient subgroups at risk will be identified.
Interventions
DIAGNOSTIC_TESTfractional sodium excretion
fractional sodium excretion will be compared to urinary sodium/creatinin, sodium/potassium ratio's and sodium concentration.
OTHERrisk subgroups
subgroup analysis will be performed to identify the patient groups at risk for sodium depletion
Sponsors
University Hospital, Ghent
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* all cystic fibrosis patients followed at the Gent University Cystic fibrosis centre * Providing a paired urine and blood sample at the time of their annual check-up
Exclusion criteria
* transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Urinary sodium/urinary creatinin (mmol/mmol) | 1 year | calculated based on urinary results |
| Fractional Potassium excretion (%) | 1 year | = (serum creatinin X urinary Potassium)/(plasma PotassiumX urinary creatinin) |
| ratio urinary sodium/urinary potassium | 1 year | = calculation of ration urinary sodium/potassium |
| fractional sodium excretion (percent) | 1 year | = (serum creatinin X urinary Sodium)/(plasma sodiumX urinary creatinin) |
| Fractional Chloride excretion (percent) | 1 year | = (serum creatinin X urinary Chloride)/(plasma Chloride X urinary creatinin) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Forced expiratory volume in 1 second | 1 year | measured with lungfunction testing expressed as % of normal for height |
| Body mass index | 1 year | = Weight/Height X Height expressed as SD of the local population based on Flemish growth charts |
Countries
Belgium
Outcome results
None listed