Cardiac Rehabilitation
Conditions
Brief summary
The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.
Interventions
OTHERProgressive High Intensity Interval Training (PRO-HIIT)
Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves progression of training of 3 stages: 1) six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min; 2) three high-intensity intervals of 2-min separated by two low-intensity intervals of 4-min, and a further 2-min of low intensity following the last interval before cool-down; and 3) three high-intensity intervals of 3-min separated by two low-intensity intervals of 3-min, and a further 1-min of low intensity following last interval before cool-down.
OTHERConstant High Intensity Interval Training (CON-HIIT)
Individual exercise training sessions, involving two weeks of moderate intensity continuous exercise and 10 weeks of interval exercise training. This protocol involves a constant protocol of training, including six high-intensity intervals (at an RPE of 15-18) of 1-min separated by five low-intensity intervals of 2-min.
Sponsors
Mayo Clinic
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult 18 years and older. * English speaking. * Able to provide consent. * Has a qualifying indication for center-based cardiac rehabilitation that is non-surgical (i.e., Acute coronary syndrome, myocardial infarction, percutaneous coronary intervention, and stable angina).
Exclusion criteria
* Participants referred to cardiac rehabilitation following coronary artery bypass surgery, heart valve repair/replacement, heart transplant, or those with ventricular assist devices. * Patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program are not eligible. * Patients unable/unwilling to provide informed consent will not be enrolled. * Patients identified as having a contraindication to high intensity exercise.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in cardiorepiratory fitness | Pre and post study completion, approximately 12 weeks | Measure as peak oxygen consumption (VO2 peak) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in locomotor muscle oxygenation | Pre and post study completion, 12 weeks | Measured as tissue oxygen saturation by near-infrared spectroscopy (NIRS) |
| Change in metaboreflex stimulation | Pre and post study completion, 12 weeks | Measured as changes in blood pressure during recovery from exercise |
| Changes in mechanoreflex stimulation and sensitization | Pre and post study completion, 12 weeks | Measured as changes in blood pressure during recovery from exercise |
| Change in cardiac function | Pre and post study completion, 12 weeks | Measured as global longitudinal strain by echocardiography at rest and during sub-maximal exercise |
| Change in oxygen uptake response time | Weekly, over 12 weeks | Measured as exponential time-constant of pulmonary oxygen uptake at exercise onset |
| Change in blood pressure | Pre and post study completion, 12 weeks | Measured as resting and mean 24-hr blood pressures by ambulatory blood pressure monitor |
| Change in blood lipids | Pre and post study completion, 12 weeks | Measured as total-cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides |
| Change in physical activity | Pre and post study completion, 12 weeks | Measured as minutes spent in moderate-vigorous physical activity, by accelerometer monitor |
| Change in body composition | Pre and post study completion, 12 weeks | Measured as fat mass by dual-energy x-ray absorptiometry |
Countries
United States
Outcome results
None listed