Covid19, Diarrhea
Conditions
Keywords
COVID-19 disease outcomes and duration, GIT manifestations, Diarrhea
Brief summary
The present study conducted to correlate symptoms not only constitutional and respiratory, but GIT as a principle presentation, with laboratory markers and COVID-19 severe acute respiratory syndrome (SARS-COV2) disease outcomes, as the duration of symptoms varies substantially between patients; the investigators undertook this study to determine the optimal time to predict COVID-19 outcomes based on real-time experience.
Detailed description
This observational retrospective cohort single center national study was conducted on patients who tested positive COVID-19 infection by the polymerase chain reaction (PCR) of nasopharyngeal sample in the period from first June to the med of July 2020. Patients were recruited from Kasr Al-Aini School of medicine, COVID-19 out-patient clinic, Cairo University hospitals. The diagnosis and classification of severity of COVID-19 infection were made according to the clinical management of COVID-19, released by the World Health Organization (WHO), mild and moderate case were recruited, the treatment protocol used was according to the Egyptian ministry of health treatment recommendations, which met in part the criteria that was later on published by the national institute of health, Mild and moderate cases once diagnosed by PCR received hydroxychloroquine 400 mg twice daily first day and maintained on 200 mg twice daily for 6 days in mild cases and 10 days in moderate cases. Also they received anticoagulants, vitamin c and zinc. In case of secondary bacterial infection, empiric antibiotics are started till result of sputum culture and sensitivity. Steroids were initiated in hypoxic cases that required supplemental oxygen and in cases of persistent symptoms. Any adult patient (age ≥18 years) suffering from mild or moderate COVID-19 infection was included in this study. While severe cases according to WHO classifications and patients aged less than18 were excluded from the study.
Interventions
hydroxychloroquine 400 mg twice daily first day and maintained on 200 mg twice daily for 6 days in mild cases and 10 days in moderate cases. Also they received anticoagulants, vitamin c and zinc. In case of secondary bacterial infection, empiric antibiotics are started
Sponsors
Cairo University
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mild and moderate COVID-19 patients:
Exclusion criteria
* Age less than 18 years * Severe COVID-19 patients: with dyspnea, hypoxia, or \>50 percent lung involvement on imaging within 24 to 48 hours * Critical COVID-19 patients: with respiratory failure, shock, or multiorgan dysfunction
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| COVID-19 disease spectrum and duration | july 2020 to june 2020 | The investigators tried to correlate disease severity with disease duration |
| GIT manifestations among COVID-19 patients | july 2020 to june 2020 | spectrum of GIT manifestations in COVID-19 patients was investigated |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Non-communicable disease and COVID-19 | july 2020 to june 2020 | The link between non-communicable disease (including diabetes, hypertension and Hypercholesterolemia) severity and COVID-19 prognosis |
| Seasonal change and COVID-19 | july 2020 to june 2020 | the investigators studied the Impact of weather climate on COVID-19 presentations (higher incidence of diarrhea in COVID-19 patients in summer) and outcomes |
| Possible region specific classification for COVID-19 disease | july 2020 to june 2020 | The investigators tried to find new Egyptian classification fro COVID-19 disease severity |
Countries
Egypt
Outcome results
None listed