Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity

Testing of a Candy in Five Different Versions for the Additional Humidification of the Oral Cavity (DESERTO)

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04554342

Acronym

DESERTO

Enrollment

Registered

2020-09-18

Start date

2020-12-28

Completion date

2021-02-18

Last updated

2021-02-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dryness of Mouth, Xerostomia

Keywords

salivary flow rate, salivary flow stimulation

Brief summary

This study is to investigate whether a candy can increase moisture of the oral cavity and reduce dryness of mouth.

Detailed description

A candy (available on the market from a Swiss manufacturer (Ricola)), free of ingredients that could interfere with the investigation, is tested in five different versions on different days. It is to analyse whether these candies can increase moisture of the oral cavity and reduce dryness of mouth.

Interventions

OTHERV01 candy

candy with sweetener (Isomalt) and apple flavour

OTHERV02 candy

candy with with sweetener (Isomalt) and apple flavour and acidifying agent (apple acid + citric acid)

OTHERV03 candy

candy with with sweetener (Isomalt) and apple flavour and acidifying agent (apple acid + citric acid) and Vitamin C

OTHERV04 candy

candy with sweetener (Isomalt) (control group 1)

OTHERV05 candy

candy with with sweetener (Isomalt) and acidifying agent (apple acid + citric acid) (control group 2)

Study design

Allocation

RANDOMIZED

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

TRIPLE (Subject, Investigator, Outcomes Assessor)

Intervention model description

doppel- blind testing of 5 different variations of a candy in each participant by (unstimulated and stimulated) salivary flow rate; each participant is testing each variation of candy once in a randomized order at 5 consecutive days

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* non- smoker * no allergies * no drug- use (except for contraception) * healthy volunteers (no disease/infection 4 weeks before study participation)

Exclusion criteria

* pregnant women

Design outcomes

Primary

Measure	Time frame	Description
dryness of mouth- sensation	one point assessment following consumption of candy (approx 5 minutes)	dryness of mouth- sensation by Visual analogue scale (VAS); 0 = does not apply; 10 = is absolutely true.
Change in salivary flow rate (ml/min)	before and after consumption of candy (approx 5 minutes for each salivary flow measurement)	Change in salivary flow rate (ml/min) before and after stimulation (mechanical and gustatory) by consumption of candy

Countries

Switzerland

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026