The Hybrid Combination of CCTA and SPECT and CAG for Evaluation Prognosis of CAD: an Observational Follow-up Study

The First Affiliated Hospital of Nanjing Medical University

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04554134

Acronym

HSCA

Enrollment

550

Registered

2020-09-18

Start date

2005-01-01

Completion date

2020-02-01

Last updated

2020-09-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Disease

Keywords

SPECT, CCTA, CAG, Hybrid

Brief summary

A total of 550 patients with stable angina (40-70% stenosis) tested by coronary CT angiography (CCTA) and single photon emission computed tomography (SPECT) and coronary angiography (CAG) within 3 months were retrospectively recruited from 2005 to 2015 and follow up to 5 years. A new hybrid software was used to analysis the image data.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 90 Years

Healthy volunteers

Inclusion criteria

1. Age: 18-70 2. Gender: All 3. coronary artery disease patients (CAD) 4. underwent CCTA, SPECT and coronary angiography (CAG) together within 3 months 5. Time: 2005-2015

Exclusion criteria

1. dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), congenital heart disease (CHD), atrial fibrillation (AF), ventricular tachycardia (VT) 2. Prior coronary revascularization; 3. permanent pacemaker or internal defibrillator 4. prosthetic heart valve 5. coronary image lose 6. coronary artery severe calcification 7. motion artifacts and poor CCTA image quality

Design outcomes

Primary

Measure	Time frame	Description
Major adverse cardiac events (MACE)	5 YEARS	All-cause death, cardiac death, ischemic stroke, unplanned revascularization and nonfatal myocardial infarction

Outcome results