Effect of Different Antihypertensive Treatment on Serum Uric Acid in Newly Diagnosed Hypertensive Patients

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04554069

Enrollment

280

Registered

2020-09-18

Start date

2021-06-01

Completion date

2022-02-28

Last updated

2021-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypertension

Brief summary

Assessment of the influence of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension patients.

Detailed description

Hypertension is the most common condition seen in primary care and leads to myocardial infarction, stroke, renal failure, and death if not detected early and treated appropriately. Thiazide-type diuretics, angiotensin-converting enzyme (ACE) inhibitors and some of angiotensin-II receptor blockers (ARB) were reported to reduce renal excretion of urate and increased serum uric acid levels, Beta-blockers also elevate serum uric acid levels. Hyperuricemia is a risk factor for cardiovascular diseases. Hyperuricemia was found to correlate with hypertension excluding the influence of other factors such as age and renal function. Furthermore, many studies found that hyperuricemia was independently associated with cardiovascular events in patients treated with antihypertensive drugs. It is important to control serum uric acid levels in hypertensive patients treated with antihypertensive drugs in order to reduce the risk of gout and cardiovascular events. There is a gap in knowledge in studies showing the effect of antihypertensive drugs on serum uric acid in newly diagnosed hypertensive patients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

30 Years to No maximum

Inclusion criteria

* All newly diagnosed hypertensive patients aged 30 years old and above will be invited to participate in this study

Exclusion criteria

1. Patients below 30 years old. 2. Patients with kidney disease. 3. Patients who are taking medications known to increase SUA as (Thiazide and Loop diuretics, Salicylates, Cyclosporin use) or decrease the level of uric acid in the urine as (Allopurinol, Febuoxstate).

Design outcomes

Primary

Measure	Time frame	Description
The effect of different antihypertensive drugs on serum uric acid in newly diagnosed hypertension.	6 months from baseline	we will measure the change of the level of serum uric acid after 6 months from the treatment of antihypertensive durgs

Secondary

Measure	Time frame	Description
obesity	6 months from baseline	it will be measured by BMI (kg/m2)

Contacts

Primary ContactMentallah Abdelrahman, MBBCH

menahallah.osama@gmail.com+201092772639

Outcome results