Cardiac Functional Disturbances During Surgery, Hyperthermia
Conditions
Brief summary
Recent data suggests that increased temperature improves inotropic function during systole and may improve diastolic function in healthy humans at rest, despite a reduction in left ventricular volume at end diastole. The effect of heat stress has not been reported in patients receiving general anesthesia and the impact of general anesthesia on these findings is not known. Trans-esophageal echocardiography will be used to measure parameters important to both systolic and diastolic function at temperature intervals of 1°C in patients undergoing Heated Intraoperative Peritoneal Chemotherapy (HIPEC.) That general anesthesia will not alter the cardiovascular effects of increased temperature that has been reported in healthy, un-anesthetized humans is the hypothesis.
Interventions
DIAGNOSTIC_TESTTransesophageal Echocardiography
Placement of a transesophageal probe and performance of a diagnostic Transesophageal echocardiography examination.
Sponsors
University of California, San Diego
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* any patient presenting for hyperthermic intraperitoneal chemotherapy.
Exclusion criteria
* Subjects less than 18 years old. * pregnant women * prisoners, * institutionalized individuals * Any patient with known contraindication to Transesophageal echocardiography. * Patients with known cardiac dysfunction prior to screening will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in ejection fraction before and after hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
Secondary
| Measure | Time frame |
|---|---|
| Transmitral inflow velocities before and after hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
| Pulmonary venous inflow velocities before and during hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
| Mitral annular tissue doppler velocities before and during hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
Other
| Measure | Time frame |
|---|---|
| heart rate before and during hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
| mean arterial pressure before and during hyperthermia | Approximately 6 hours from prior to hyperthermia to during hyperthermia. |
Countries
United States
Outcome results
None listed