Alcoholism, Stress Disorders, Post-Traumatic
Conditions
Brief summary
The present study seeks to increase understanding of Alcohol Use Disorder (AUD) and Posttraumatic Stress Disorder (PTSD) among veterans, an important public health concern. We will study the effects of regulatory deficits and sleep disturbance on the dynamic course of PTSD and AUD. The study will investigate whether a short, computerized training in the laboratory will alter maladaptive response biases and reduce associations between sleep disturbance, affect and behavioral dysregulation, AUD symptoms, and PTSD symptoms in the real world.
Interventions
BEHAVIORALAlcohol CBM
Trains approach or avoidance responses to alcohol cues.
BEHAVIORALPTSD CBM
Trains approach or avoidance responses to trauma cues.
BEHAVIORALAlcohol Sham
Will not train approach or avoidance responses.
BEHAVIORALPTSD Sham
Will not train approach or avoidance responses.
Sponsors
National Institute of Mental Health (NIMH)
Sioux Falls VA Health Care System
Bay Pines VA Healthcare System
University of South Dakota
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* OIF/OEF/OND veterans * At risk for PTSD (i.e., PCL-5 ≥33) and/or AUD (i.e., AUDIT ≥ 7 (women) ≥ 8 (men))
Exclusion criteria
* Psychosis or severe Alcohol Use Disorder that contraindicates participation (based on interview) * Active suicidal or homicidal ideation that contraindicates participation (based on interview) * \[
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of Alcohol Use Disorder Symptoms | 2 years | These are experience sampling items derived from Diagnostic and Statistical Manual of Mental Disorders (DSM-5). |
| Rate of PTSD Symptoms | 2 years | These are experience sampling items derived from the PTSD Checklist from DSM-5 (PCL-5). |
Countries
United States
Contacts
Primary ContactJeffrey S Simons, PhD
Backup ContactRaluca M Simons, PhD
Outcome results
None listed