High-dose Biapenem
Conditions
Keywords
High-dose Biapenem, Carbapenem resistance Klebsiella pneumoniae, Clinical Efficacy
Brief summary
Carbapenem resistance is a high mortality rate of Klebsiella pneumoniae infection. It has been proved that high-dose carbapenem can reduce mortality and has a certain clinical effect. In this study, a high dose of biapenem was compared to determine whether it had a similar effect than meropenem.
Interventions
DRUGBiapenem
In the course of CRKP treatment, double dose biapenem was selected.
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
14 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* ICU hospitalized for more than 3 days; * Biapenem used for more than 3 days
Exclusion criteria
* Patients who refuse to be included in the group or pregnant women or under the age of 14 or ICU hospitalized for less than 3 days
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality | 2017.01.01-2021.12.31 |
Secondary
| Measure | Time frame |
|---|---|
| Clearance rate of pathogenic microorganisms | 2017.01.01-2021.12.31 |
| ICU hospitalization days | 2017.01.01-2021.12.31 |
Countries
China
Contacts
Primary ContactMan Huang, Ph D
Outcome results
None listed