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Mannose Binding Lectin Gene Polymorphism Versus Microbial Virulence in the Pathogenesis of Vulvovaginal Candidiasis

Mannose Binding Lectin Gene Polymorphism Versus Microbial Virulence in the Pathogenesis of Vulvovaginal Candidiasis in Egypt

Status
UNKNOWN
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT04552210
Enrollment
50
Registered
2020-09-17
Start date
2020-09-16
Completion date
2021-02-20
Last updated
2020-11-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Infection

Brief summary

The vaginal mucosa is inhabited by both fungal and bacterial microorganisms which normally co-exist with the host in a tightly regulated and commensal manner.

Detailed description

Nevertheless, under certain circumstances, this co-existence can turn into a pathologic state followed by symptomatic disease

Interventions

DIAGNOSTIC_TESTblood sample

Whole blood was collected on EDTA (1mg/ml) to prevent clotting and DNA degradation.

Sponsors

Cairo University
CollaboratorOTHER
Aljazeera Hospital
Lead SponsorOTHER

Study design

Observational model
OTHER
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 42 Years

Inclusion criteria

* 1\. Married females in the reproductive age period. 2. Females complaining of vaginal discharge (whitish and scanty), itching, dyspareunia, pruritis, and signs of vulvovaginitis ie. erythema.

Exclusion criteria

* females who attended the same clinic in the same period, matched the cases regarding the age group, without having Candida infection as confirmed by culture of vaginal swabs.

Design outcomes

Primary

MeasureTime frameDescription
the number of women who have mutation in MBL2 gene polymorphisma monthwomen who have mutation in MBL2 gene polymorphism

Countries

Egypt

Contacts

Primary ContactMahmoud Alalfy
mahmoudalalfy@ymail.com01002611058
Backup ContactAhmed Elgazzar
elgazzara50@gmail.com01014005959

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026