Latent Tuberculosis
Conditions
Brief summary
This study will evaluate new technique, microneedle, to detect latent tuberculosis (TB) in healthy volunteers
Detailed description
The cross-sectional study to investigate the effect of microneedle formulations and lengths of Tuberculin PPD microneedles on the delayed-type hypersensitivity response in healthy volunteers.
Interventions
DIAGNOSTIC_TESTTST vs PPD microneedle test
TST vs First patch: 800 um in length, PPD1 formulation; Second patch: 1,500 um in length, PPD1 formulation; Third patch: 800 um in length, PPD2 formulation; and Fourth patch: 1,500 um in length, PPD2 formulation
Sponsors
National Nanotechnology Center (NANOTEC), The National Science and Technology Development Agency (NSTDA)
The HIV Netherlands Australia Thailand Research Collaboration
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
1. Sex : Male and Female 2. Age : 20-60 years 3. TB contacts or those at risk of TB e.g. health-care workers 4. HIV-negative healthy individuals
Exclusion criteria
1. Presence of an acute infection, as determined by investigators 2. Receiving immunosuppression drugs e.g. steroids 3. Having autoimmune diseases e.g. SLE (Systemic Lupus Erythematous) 4. Being pregnant or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| size of induration at 48 hours post-PPD injection | 48 hours | Monitoring the response of delayed-type hypersensitivity on the skin by comparing TST to microneedle tests |
Countries
Thailand
Outcome results
None listed