ST-segment Elevation Myocardial Infarction (STEMI)
Conditions
Brief summary
To investigate the predictive value of PRECISE DAPT score in relation to coronary slow flow & other short term major adverse cardiovascular events (MACE) post PPCI .
Detailed description
Coronary artery disease (CAD) is the leading cause of death around the world and more than 4 million people die every year due to CAD in Europe.\[1\] The incidence of ST elevation myocardial infarction (STEMI) appears to be declining; however, it is still an important issue in cardiovascular medicine.\[2\] Initial risk assessment is important for STEMI to estimate adverse cardiovascular outcomes. Previous studies demonstrated that increased age, advanced Killip class, heart rate, arterial hypotension, increased serum creatinine, white blood cell counts, and hemoglobin levels were predictors of in-hospital and early mortality in patients with STEMI treated with primary percutaneous coronary intervention (PPCI).\[3,4 \]Therefore, risk scores including the aforementioned parameters were developed to estimate mortality in patients with STEMI. No-reflow is still a challenging major issue in the management of the patients with STEMI undergoing primary PCI. It is defined as inadequate myocardial perfusionthrough a given segment of the coronary circulation without angiographic evidence of mechanical vessel obstructionas \[5\] Angiographic no-reflow defined as less than Thrombolysis In Myocardial Infarction (TIMI) 3 flow \[6\] and angiographic success was defined as TIMI Grade 3 Flow . PRECISE-DAPT score includes age, creatinine clearance, white blood cell counts, hemoglobin levels, and prior spontaneous bleeding \[7\]. All these factors have a close relationship with coronary artery disease (CAD) and complications \[8-10\]. Therefore, in this study, we aimed to evaluate the association of admission PRECISE-DAPT score with the development of slow flow & bleeding & othershort term cardiovascular complications that develop in patients with STEMI treated with primary PCI.
Interventions
OTHERcalculate PRECISE DAPT score using clinical data
calculate PRECISE DAPT score using clinical data in STEMI patients after PPCI
Sponsors
Assiut University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
1.Subjects diagnosed as STEMI accordind to fourth universal definition with age range from 18 to 75 years underwent PPCI at cardiology hospital assiut university hospital.\[11\]. 2..Patients elegable for PPCI with STEMI within 12 h of symptom onset, provided it can be performed expeditiously (i.e. 120 min from STEMI diagnosis)\[12\] \-
Exclusion criteria
1-late presentation with STEMI more than 12 hr & door to ballon more than 120 min including rescue PCI . 2- cardiogenic shock 3-Patients known to have autoimmune disease (e.g vasculitis ) 4- platelate count less than 100000 IU . 5- prothrombin concentration less than 60% 6- Patients taking triple anti thrombotics . \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Follow up complications after PPCI | 3 months | calculating PRECISE DAPT score and follow up patients for three months whether these complications as coronary slow flow &primary MACE &secondary MACE &bleeding |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Predictive value of PRECISE DAPT score | 3 months | Whether there is relation between PRECISE DAPT score &post PPCI short term complications or not |
Contacts
Primary ContactMadonna Atef, Resident
Backup ContactHatem Abd-Elrahman, Professor
Outcome results
None listed