Stroke
Conditions
Brief summary
The purpose of this study is to identify the characteristics of neural plasticity seen in stroke patients by measuring the changes in brain activity during stimulation using functional near-infrared spectroscopy (fNIRS) when applying transcranial direct current stimulation (tDCS) for the purpose of enhancing finger function.
Interventions
DEVICETranscranial direct current simulation
Four sessions of stimulation over C3 (patient with left-sided lesion) or C4 (patient with right-sided lesion) based on 10-20 system
Sponsors
Samsung Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
19 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* Unilateral stroke patients * Chronic patients over 6 months after onset * Subcortical stroke * Patients with the movement of fingers
Exclusion criteria
* History of psychiatric disease * Significant other neurological diseases except for stroke * Difficult to perform this experiment * Patients with metal implants * History of epilepsy * Pregnancy * Skin defect at the site of electrode attachment
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in cortical activity using fNIRS signals during brain stimulation | Baseline and about 10 days (immediately after brain stimulation sessions) | Cortical activities before and after brain stimulation sessions are compared. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| 9-hole pegboard test | Baseline and about 10 days (immediately after brain stimulation sessions) | The test is a standardized, quantitative assessment used to measure finger dexterity of a patient. |
| Grip & Tip pinch strength test | Baseline and about 10 days (immediately after brain stimulation sessions) | The test is to measure the maximum isometric strength of hand, forearm, and finger muscles. |
| Changes in motor evoked potential | Baseline and about 10 days (immediately after brain stimulation sessions) | Resting motor threshold (rMT) and amplitude of motor evoked potential in first dorsal interosseous muscle are measured. These outcomes are measured by transcranial magnetic stimulation over the motor hotspot. The rMT is defined as the minimum stimulus intensity that produced a minimal motor evoked response at rest. The amplitude means peak to peak of the muscle response. |
| Fugl-Meyer Assessment | Baseline and about 10 days (immediately after brain stimulation sessions) | The score is a stroke-specific, performance-based impairment index. The degree of impairment of upper and lower limbs is measured. |
| Finger tapping test | Baseline and about 10 days (immediately after brain stimulation sessions) | Response time is measured during finger tapping task. |
| Box & Block test | Baseline and about 10 days (immediately after brain stimulation sessions) | The test is used to measure the gross manual dexterity of a patient, or of a person using an upper limb prosthetic device. |
Countries
South Korea
Outcome results
None listed