Metaplastic Breast Carcinoma
Conditions
Brief summary
prospective study for response of neoadjuvant chemotherapy in metaplastic carcinoma of triple negative breast cancer
Detailed description
Vimentin/Pan CK staining will be performed on tissues of patient who visited Seoul National University Hospital and were diagnosed with triple negative breast cancer and decided to perform neoadjuvant chemotherapy under clinical judgement. Histologically determined to be a metaplastic breast cancer or tested positive for vimentin/Pan CK patients decides as the metaplastic breast cancer. They evaluate the response rate of the neoadjuvant chemotherapy. Patients with vimentin/Pan CK negative are diagnosed with non-metaplastic breast cancer and this group also confirms the response rate of neoadjuvant chemotherapy. The group of metaplastic breast cancer will enroll 50 people, and the group of non-metaplastic breast cancer will enroll 100 people.
Interventions
DIAGNOSTIC_TESTVimentin/pan CK stain
Vimentin/pan CK stain positive/negative
Sponsors
Seoul National University Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Inclusion criteria
* over 20 years old * patients with triple negative breast cancer diagnosed Seoul National University Hospital * patients who decided to perform neoadjuvant chemotherapy under clinical judgement
Exclusion criteria
* not applicable
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| response rate of neoadjuvant chemotherapy | After neoadjuvant chemotherapy was finished. Average 6 month later. | response criteria for neoadjuvant chemotherapy-complete response (CR), partial response (PR), and no response (NR) |
Countries
South Korea
Outcome results
None listed