Air Pollution, Pregnancy
Conditions
Keywords
immune function
Brief summary
The purpose of this project is to study the effects of air pollution toxicants on pregnant mothers' immune health during and after pregnancy. Using already collected samples, this study proposes to evaluate changes in immune function in response to air pollution with the use of innovative technologies, to identify the drivers of immune dysfunction and potential modifiable factors, and to determine how these immune findings are associated with pollution exposure and outcomes of disease.
Interventions
OTHERThere is no intervention
There is no intervention
Sponsors
National Institute of Environmental Health Sciences (NIEHS)
Duke University
Stanford University
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Pregnant women: at 18-25 weeks gestation at time of eligibility screening and baseline visit
Exclusion criteria
* Having smoked more than 50 cigarettes during pregnancy * A history of autoimmune diseases, HIV or cancer
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in immune cell subset identity and function in pregnant vs. non pregnant women exposed to high vs. low pollution over time | 3 years |
| Identify the epigenetic molecular mechanisms driving immune dysfunction in pregnancy vs. no pregnancy with high vs. low PM2.5 exposure over time | 3 years |
| Map T cell receptor diversity to immune dysfunction in pregnancy vs non pregnancy with high vs. low PM2.5 exposure over time | 3 years |
Countries
United States
Outcome results
None listed