Bloodstream Infection (BSI)
Conditions
Keywords
cardiovascular surgery, cardiopulmonary bypass (CPB), nosocomial infection, early bloodstream infection, postoperative septicaemia
Brief summary
This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
Detailed description
Infectious complications after cardiovascular surgery, especially in operations that use cardiopulmonary bypass (CPB), is associated with significant morbidity and increase in peri-operative mortality. Prolonged CPB usage could be predictive for early bloodstream infection following cardia surgery. This study is to analyse the demographics and microbiological factors concerning patients undergoing cardio surgical intervention using CPB complicated with bloodstream infection (BSI) postoperatively.
Interventions
None listed
Sponsors
University Hospital, Basel, Switzerland
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* adult patients undergoing cardiac surgery
Exclusion criteria
* patients having active or previous endocarditis * patients whose causative microorganism of postoperative BSI was identical to that isolated from preoperative or intraoperative samples * patients with common skin colonized microorganisms, such as coagulase-negative Staphylococci, Viridans group Streptococci, Corynebacterium species, Bacillus species, Propionibacterium species, and Aerococcus species or Micrococcus species, which were isolated from only a single blood sample and without evidence of clinical sepsis, because contamination was considered.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample) | within 7 days after a cardiovascular surgery | Incidence of bloodstream infection (BSI) in postoperative period (clinical evidence of sepsis with laboratory-confirmed bacteraemia from blood sample) |
| Extracorporeal circulation time during surgery (minutes) | one time assessment at baseline | Extracorporeal circulation time during surgery (minutes) |
| In-hospital mortality (number) for patients with BSI vs those without BSI after a cardiovascular surgery | during hospital stay (usually up to 4 weeks) | In-hospital mortality is defined as death before discharge |
| Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay (number) | during hospital stay (usually up to 4 weeks) | Surgical intervention rate (Incidence of cardiovascular re-operation) during the initial hospital stay |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of cardiovascular events (stroke, myocardial infarction) during follow-up | after hospital discharge until follow- up assessment (up to 10 years) | Incidence of cardiovascular events (stroke, myocardial infarction) during follow-up |
| Incidence of cardiovascular re-operation during the follow up | after hospital discharge until follow- up assessment (up to 10 years) | Incidence of cardiovascular re-operation during the follow up |
| Incidence of cardiovascular events (stroke, myocardial infarction) during hospitalization | during hospital stay (usually up to 4 weeks) | Incidence of cardiovascular events during hospitalization |
Countries
Switzerland
Outcome results
None listed