Artificial Intelligence, Otolaryngological Disease
Conditions
Keywords
Nasopharyngeal Carcinoma, Endoscopy, Narrow-Band Imaging, White-Light Imaging
Brief summary
Nasopharyngeal carcinoma (NPC) occurs at a high frequency in southern China, northern Africa, and Alaska, with a reported incidence of 30 cases per 100 000 in Guangdong Province. Endoscopic examination and biopsy are the main methods used for detection and diagnosis of NPC. Early NPC patients achieve favourable prognoses after concurrent radiotherapy and chemotherapy in compassion with advanced NPC patients. Here, the investigators focused on the utility of artificial intelligence to detect early NPC, which based on white light imaging (WLI) and Narrow-band imaging (NBI) nasoendoscopic examination. Having access to this unique population provides an unprecedented opportunity to investigate the effect of intelligent system on diverse nasopharyngeal lesions detection and develop a novel Computer-Aided Diagnosis System.
Interventions
DIAGNOSTIC_TESTrigid nasal endoscopes
The endoscope is introduced through the nasal passage to observe, in sequence, the posterior nostril, superior and posterior walls of the nasopharynx, torus tubarius, pharyngeal opening of the auditory tube, and Rosenmu¨ller recess. The imaging light mode is set to conventional WLI and subsequently switch to NBI during the procedure, and representative images are collected and preserve for further analysis. All lesions, detected by either WLI or NBI, are biopsied.
Sponsors
Sun Yat-sen University
First Affiliated Hospital, Sun Yat-Sen University
Study design
Observational model
OTHER
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Inclusion criteria
* Older than 18 years of age
Exclusion criteria
* Refuse to sign the informed consent statement * Patients who have contraindications, e.g. coagulation dysfunction, drug allergy.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pathological diagnosis | baseline | All lesions, detected by either WLI or NBI, are biopsied. 2 experienced pathologists, who were blinded to the endoscopic and intelligent assessment, evaluate the pathological nature of the biopsied lesion independently, and 2 professors with over 10 years of experience in Otolaryngology and pathology department are consulted in cases of disagreement. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Lesion range | baseline | All images in which lesions are pathologically diagnosed as NPC are collected. 2 experienced pathologists, who were blinded to the endoscopic and intelligent assessment, delineated the malignant area in the images independently, and 2 professors with over 10 years of experience in Otolaryngology department are consulted in cases of disagreement. |
Countries
China
Contacts
Primary ContactYihui Wen, Ph.D
Backup ContactRui He, M.D.
Outcome results
None listed