Gynecological Disorder
Conditions
Keywords
Pain, Propofol, Rocuronium, Temporal summation.
Brief summary
Temporal summation of pain, which is defined as the perception of increasingly greater pain evoked by repetitive painful stimuli, is highly variable between individuals. This study aimed to determine the impact of the timing of rocuronium after induction with propofol on temporal summation of pain in gynecologic laparoscopic surgery.
Interventions
OTHERThe difference of the timing of rocuronium administration after propofol injection
The difference of the timing was rocuronium was administered immediately after propofol injection or when BIS score became below 60 after propofol administration.
Sponsors
Wonkwang University Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Masking description
Attending anesthesiologist knew which anesthetic agents were used. However Outcomes assessor didn't know which anesthetic agents were used.
Intervention model description
One hundred patients, between 18-60 years of age were randomly assigned to one of the two groups; group PRi received immediate injection of rocuronium after propofol administration, and group PRd received rocuronium injection when bispectral index score became below 60 after propofol administration
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Elective gynecologic laparoscopic surgery * American Society of Anesthesiologists' physical status class) I-II
Exclusion criteria
* Menopause (to exclude the hormonal effect on pain) * Patients who had muscular, cardiovascular, hepatic or kidney disorders and patients with a history of medication who would affect muscle relaxants were excluded from this study. * Patients with difficult venous access on forearm, a known allergy to propofol or rocuronium, chronic pain, pregnancy, and those who had received analgesics or sedatives within the previous 24 hours, were excluded from the study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the grade of rocuronium induced withdrawal movement. | during anesthesia induction | withdrawal movements were graded by the investigator according to the following scale: 1. \- no pain (no response); 2. \- mild pain (movement at wrist only); 3. \- moderate pain (movement involving the arm only with elbow or shoulder); 4. \- severe pain (generalized response or movement in more than one extremity |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| visual analog scale (VAS) for injection pain | during anesthesia induction | check VAS for pain after propofol administration. visual analog scale with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain |
| VAS for pain | at 1 hour, 24 hours and 48 hours | check VAS with 100 mm for pain after surgery. 0 = no pain, 100 = the worst pain |
| Patient controlled analgesia (PCA) Opioid consumption | at 24 and 48 hours | check the volume of PCA Opioid consumption (ml) (PCA) pump containing fentanyl (800 ug), ketorolac (150 mg), and ramosetron (0.6 mg) in a total volume of 150 mL of saline was set to deliver a basal infusion of 2 mL/h and bolus doses of 0.5 mL, with a 15-min lockout period for postoperative analgesia. |
Countries
South Korea
Outcome results
None listed