Hunger, Insulin Sensitivity, Metabolic Rate
Conditions
Brief summary
About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured every hour for four hours on each occasion starting in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal.
Detailed description
About 14 healthy participants, consume a standardized breakfast combined with either using regular or nicotine-free moist snuff. The metabolic rate is measured measured before the meal and then every hour for a total of four hours on each occasion that starts in the morning. Participants are also randomized to get red wine or non-alcoholic red wine to the meal. Since there are four possible combinations of the wine and the snuff, all participants do the test on four occasions. Except for metabolic rate we will also analyze hormone responses regarding appetite or hunger.
Interventions
OTHERWine with or without alcohol and snuff with or without nicotine
Two by two factorial of wine and snuff with meals
Sponsors
University Hospital, Linkoeping
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Masking description
We use non-alcoholic or alcohol containing wine and regular or nicotine free snuff
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
No significant disease -
Exclusion criteria
known illnesses, thyroid disease, need to take prednisolone, psychiatric disease,inability to understand Swedish \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| level of metabolic rate | 4 hours | Measurement of metabolic rate by registration of CO2 in breath and the oxygen uptake |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| sense of appetite | 4 hours | determination of the hormones ghrelin and GLP-1 in serum |
Countries
Sweden
Outcome results
None listed