Cardiac Death, Heart Failure, Heart Failure With Reduced Ejection Fraction
Conditions
Brief summary
Suboptimal optimization of atrio-ventricular (AV) and inter-ventricular (VV) timings could affect the clinical response of CRTd in T2DM patients. Thus, authors hypothesize that automatic sensor guided CRTd optimization could ameliorate clinical outcomes in patients with T2DM. However, authors will evaluate the effects of cardiac resynchronization therapy (CRTd) in patients with type 2 diabetes mellitus (T2DM) optimized via automatic vs. echocardiographic guided approach.Authors will conduct a prospective, multicenter study to recruit, from October 2016 to June 2019, patients with T2DM and heart failure (HF) candidate to receive a CRTd. After CRTd the patients will be optimized via automatic vs. echocardiographic guided approach.
Interventions
OTHERechocardiographic optimization of CRTd
the patients after the implant of CRTd and during the follow-up will receive an echocardiography to optimize the atrio-ventricular and inter-ventricular delay, and to improve the effects of CRTd.
Sponsors
University of Campania Luigi Vanvitelli
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* heart failure with reduced cardiac pump, NYHA class II/III, indication to receive a CRTd.
Exclusion criteria
* NYHA class IV, previous CRTD implantation, neoplastic disease, inflammatory chronic disease.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| CRTd responders rate | 12 months | The authors will evaluate the CRTd responders rate in terms of patients that will experience the reduction of NYHA class, improvement of HF symptoms, and improvement of left ventricle ejection fraction. |
Countries
Italy
Outcome results
None listed