SARS-CoV-2 Infection
Conditions
Brief summary
Recently published studies could demonstrate that detection of specific biomarkers in breath could be applied for the diagnosis of SARS-CoV-2.
Detailed description
In this study we want to address the sensitivity and specificity of breath analysis by MCC-IMS in the context of SARS-CoV-2 detection from PCR- proven infected and non-infected subjects. Therefore nasal breath will be aspirated for 10 seconds during normal respiration by a foam cuffed oxygen catheter connected via a 0.22μm filter and a line into the MCC-IMS and directly analyzed without any pre-analytic procedures. The during the proof-of-concept study derived significant peaks for volatile organic compounds will be used for discrimination in a point-of-care approach.
Interventions
DIAGNOSTIC_TESTMulticapillary column coupled ion mobility spectrometry
sampling of nasal air via a foam cuffed oxygen catheter
Sponsors
Klinikum Bayreuth GmbH
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
hospital admission staff members
Exclusion criteria
too sick to comply with study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| correct classification of SARS-CoV-2 infected and not infected subjects | 6 months | correct classification of SARS-CoV-2 infected and not infected subjects |
Countries
Germany
Outcome results
None listed