Cesarean Section, Postoperative Pain
Conditions
Brief summary
In this prospective randomized trial, investigators compared the analgesic effect of subanesthetic dose of ketamine versus placebo in parturients undergoing cesarean section under spinal anesthesia.
Detailed description
In this prospective randomized trial, investigators compared the analgesic effect of subanesthetic dose of ketamine versus placebo in parturients undergoing cesarean section under spinal anesthesia. The patients were randomized in two groups: * Group Ketamine: these patients recieved 0.25 mg/kg of Ketamin intravenously 5 minutes after the spinal anesthesia. * Group Placebo: recieved 20 ml of normal saline solution intravenously 5 minutes after the spinal puncture. The investigators recorded intra demographic, intraoperative and post operative data. The main outcome was the analgesic score: the visual analog scale (VAS). dynamic VAS was also monitored at 24 hours post operatively.
Interventions
DRUG0.25 mg/kg of Ketamine
patients will recieve 0.25mg/kg of ketamine intravenously 5 min after spinal anesthesia
DRUG20ml of normal saline solution
20ml of normal saline solution intravenously 5 minutes after spinal anesthesia
Sponsors
Mongi Slim Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Caregiver)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* full term pregnant adult patients * Monofetal pregnancy * scheduled for urgent or elective cesarean section under spinal anesthesia
Exclusion criteria
* necessity of general anesthesia during the procedure * Post partum hemorrage
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Dynamic Visual Analog Scale | 24 hours after cesarean section | Pain score VAS range from 0 to 10, high scores mean worse outcome |
Countries
Tunisia
Outcome results
None listed