Supraglottic Airway Device Insertion
Conditions
Brief summary
The aim of this study is to compare the degree of change in the angle of the vocal cords before and after administration of neostigmine or sugammadex. Moreover, we intend to compare the angle of vocal folds after administration of neostigmine or sugammadex.
Interventions
DRUGSugammadex
Administration of Sugammadex for muscle relaxation reversal
DRUGNeostigmine
Administration of Neostigmine for muscle relaxation reversal
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Masking description
triple (Participant, Care Provider, investigator)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1\. Adult patients who undergoes elective surgery under general anesthesia with supraglottic airway device.
Exclusion criteria
1. Patients under 20 years old 2. Pregnant women 3. Patients who can not read the consent form or are not fluent in Korean (illiterate, foreigner) 4. Patients who refused the clinical trial 5. Patients with dementia or cognitive impairment 6. Patients with neuromuscular disorders impairing neuromuscular blockade 7. Renal dysfunction (estimated Glomerular Filtration Rate less than 30 ml/min/1.73m2) 8. Past history of allergic reactions to neostigmine or sugammadex 9. Patients with ASA class IV or higher 10. Robotic surgery, adenoid or tonsillectomy 11. Patients with moderate or severe asthma, pulmonary function tests with forced expiratory volume for 1second of 1 liter or less, patients with upper respiratory infection symptoms within 2 weeks before surgery, current smokers (within 1 month of smoking cessation is included.)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Angle of vocal folds after administration of sugammadex or neostigmine 2) Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine | 1-2 minutes after drug administration (inhalation, exhalation) |
| Degree of change in angle of vocal folds before and after administration of sugammadex or neostigmine | 1) Just before drug administration 2) 1-2 minutes after drug administration (inhalation, exhalation) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Time to recover from spontaneous breathing | immediately after drug(sugammadex or neostigmine) administration | Time taken to recover from spontaneous breathing(6ml/kg or more) after administration of sugammadex or neostigmine |
| Time to extubation | immediately after drug(sugammadex or neostigmine) administration | Time taken to extubation after administration of sugammadex or neostigmine |
Contacts
Primary ContactJeong-Rim Lee
Outcome results
None listed