Stress Response
Conditions
Brief summary
this study is designed to assess the efficacy of MgSO4 versus high dose fentanyl compared to conventional anesthesia in attenuating stress response to intubation
Detailed description
to assess the effect of MgSO4 combined with fentanyl compared to high dose fentanyl in attenuating stress response in cancer patients undergoing surgeries under general anesthesia requiring endotracheal intubation
Interventions
DRUGMagnesium sulfate- Fentanyl
drug administration before intubation
DRUGFentanyl 4Mcg/kg
drug administration with induction of anesthesia
DRUGFentanyl 2Mcg/kg
drug administration with induction of anesthesia
DRUGLidocaine 1.5 mg/kg
drug administaration 90 sec before intubation
Sponsors
National Cancer Institute, Egypt
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
* Cancer patients undergoing surgery under general anesthesia requiring endotracheal intubation * ASA I II * 18 to 60
Exclusion criteria
* allergy to any of the used drugs * renal or hepatic impairment * hypertensive patients, patients with cardiovascular or cerebrovascular diseases
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| heart rate values | 5 minutes | changes in heart rate values after intubation |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| blood pressure | 5 minutes | mean arterial blood pressure values |
| coughing during intubation | lntubation time | coughing during intubation |
Countries
Egypt
Outcome results
None listed