ARDS, Human, Corona Virus Infection, Sepsis
Conditions
Brief summary
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring intensive care unit (ICU) -care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish adult respiratory distress syndrome (ARDS) -cohort.
Detailed description
The Corona virus disease 2019 (COVID-19) pandemic is currently involving all parts of the world. Several risk factors for critical illness and death from the disease have been proposed. However, it is still unclear if the observed associations between different comorbidities and chronic medications and severe COVID-19 disease and mortality is different from associations between the same factors and other severe diseases requiring ICU-care. This is important since some of the observed risk factors are very common in the aged who, by age alone, are more prone to a more severe course of any disease. By combining several registries, this study will compare, on several comorbidities such as hypertension and diabetes , the first 2000 cases of COVID-19 patients receiving critical care in Sweden to a Swedish sepsis-cohort and a Swedish ARDS-cohort.
Interventions
Sponsors
Center for Clinical Research Dalarna, Sweden
Uppsala University
Study design
Observational model
COHORT
Time perspective
OTHER
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
° Individual registered in the Swedish intensive care registry (SIR) with COVID-19 Before 27 May 2020. or * Individual registered in the SIR with Severe sepsis or septic chock 2011-2016. or * Individual registered in the SIR with ARDS 2011-2016.
Exclusion criteria
* Age below 18 years * Individual registered in the Swedish intensive care registry without a personal identification number
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Risk factors of ICU care COVID-19/Sepsis | Five years preceding ICU admission to ICU admission | In a binary logistics model with the outcome Sepsis or COVID-19 the OR for several comorbidities are determined. |
| Risk factors of ICU care COVID-19/ARDS | Five years preceding ICU admission to ICU admission | In a binary logistics model with the outcome ARDS or COVID-19 the OR for several comorbidities are determined. |
| Risk factors of ICU mortality COVID-19/Sepsis | Five years preceding ICU admission to ICU discharge | In a Cox proportional hazards model with the outcome ICU-mortality the hazard ratio (HR) for the interaction between several comorbidities and a binary variable COVID-19/Sepsis are determined. |
| Risk factors of ICU mortality COVID-19/ARDS | Five years preceding ICU admission to ICU discharge | In a Cox proportional hazards model with the outcome ICU-mortality the HR for the interaction between several comorbidities and a binary variable COVID-19/ARDS are determined. |
Countries
Sweden
Outcome results
None listed