Non-surgical Peridontal Treatment on Cardiovascular Risk Markers

Effect of Non-surgical Peridontal Treatment on Cardiovascular Risk Markers in Patients With Severe Chronic Periodontitis

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT04540328

Enrollment

Registered

2020-09-07

Start date

2015-08-31

Completion date

2017-08-31

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular Risk Markers, Chronic Periodontitis

Keywords

asymmetric dimethylarginine, endothelial nitric oxide synthase, homocysteine, monocyte chemoattractant protein-1

Brief summary

The study evaluates the influence of non-surgical mechanical periodontal treatment in patients with severe chronic periodontitis on inflammatory markers related to risk for cardiovascular diseases

Detailed description

A total of 80 non-smokers with systemically healthy, including 40 patients with severe chronic periodontitis and 40 periodontally health subjects were included into the present study. The probing depth, clinical attachment level, plaque index, gingival index and blood samples were collected at baseline and at the 3rd months after treatment and the serum levels of asymmetric dimethylarginine (ADMA), endothelial nitric oxide synthase (eNOS), homocysteine (Hcy), monocyte chemoattractant protein-1 (MCP-1) were determined with enzyme-linked immunosorbent assay (ELISA).

Interventions

OTHERNon-surgical periodontal treatment

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

30 Years to 54 Years

Healthy volunteers

Yes

Inclusion criteria

Clinical diagnosis of severe chronic periodontitis Clinical diagnosis of periodontal health

Exclusion criteria

Systemic diseases such as diabetes, cardiovascular disease Periodontal treatment within the previous year Drugs such as systemic steroids, non-steroidal anti-inflammatory drugs, immunosuppressants, hormone drugs, contraceptives, anticoagulants, cholesterol regulating drugs, systemic antibiotics, antioxidants within the previous 3 months Pregnant or lactating Consumed alcohol Smoker

Design outcomes

Primary

Measure	Time frame	Description
Asymmetric dimethylarginine (ADMA)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (pg/mL)
Endothelial nitric oxide synthase (eNOS)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (pg/mL)
Homocysteine (Hcy)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (nmol/mL)
Monocyte chemoattractant protein-1 (MCP-1)	At the 3rd months after non-surgical periodontal treatment	Serum Concentration (ng/mL)

Secondary

Measure	Time frame	Description
Clinical periodontal parameter	At the 3rd months after non-surgical periodontal treatment	Clinical attachment level (mm)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026