Arterial Stiffness, Magnetic Field Exposure, Peripheral Arterial Disease
Conditions
Brief summary
The purpose of this research study is to investigate and determine the effects of static magnetic fields produced by a small magnet on peripheral pulses and skin blood flow.
Detailed description
A specific neodymium magnet and sham device will be placed on certain sites near the ulnar and medial arteries and the effect of such placement on peripheral pulses assessed via PPG on fingers and on skin blood flow via laser Doppler perfusion determined. These assessments will be made while healthy subjects are lying supine on a padded examination table over a time interval of about 45-60 minutes. In addition to the impact that either the magnet or the sham devices have, the pulse and skin blood flow patterns and features will be analyzed from the point of view of sequential variability with and eye toward developing related parameters to potentially improve such variability.
Interventions
DEVICEmagnet and sham
In same subject some areas will have magnet and others will have sham
Sponsors
Nova Southeastern University
Study design
Allocation
RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Masking description
Subjects and coinvestigators making measurements are blinded to which devices are the active magnets and which are the sham magnets. Only the PI will have that information.
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
1. Age between 18-35 years 2. No known neurological deficit 3. No known cardiovascular condition
Exclusion criteria
1. Unable or unwilling to lie reasonably still for about 55 minutes 2. Known to have diabetes of any type 3. Having any metallic or wire implant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of magnet on skin blood flow | one hour | skin blood flow |
| Effect of magnet on arterial pulses | one hour | Pulse values and paterns |
| Characterization of temporal pattern of pulse changes and their amelioration | one hour | variability with and without normalization |
Countries
United States
Outcome results
None listed