Controlled Ovarian Hyperstimulation (COH) With Sequential HPFSH & HMG Versus Rec-F.S.H Alone in ICSI Cycle

Status

UNKNOWN

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04539613

Enrollment

100

Registered

2020-09-07

Start date

2020-09-01

Completion date

2021-02-01

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ovarian Stimulation in ICSI

Brief summary

despite the large number of papers published on COH protocols comparing the efficiency of different exogenous gonadotropins, no confirmed protocol exists, and it is not quite clear which is superior to the others.

Detailed description

, the objective of the current study was to compare the efficacy of 2 different ovarian stimulation protocols, comprising hpFSH, HMG versus R-FSH on oocyte and embryo quality and IVF treatment outcome in patients undergoing IVF or intracytoplasmic sperm injection (ICSI)(4).

Interventions

DRUGHPFSH & HMG

. Various gonadotropin preparations

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 35 Years

Inclusion criteria

* 1-Aged 20-35 yr, male factor, 2-Tubal or unexplained infertility, 3-regular menstruation cycle between 21 and 35 days, 4-Normal function of uterus according to hysterosalpingography, hysteroscopy or transvaginal ultrasonography, 5-Normal ovaries according to transvaginal ultrasonography during past 6 months prior to study and compatible with normal adnexa and 6-Normal ovarian anatomy, and serum FSH level less than 8 IU/l All women showed no recognizable endometriosis according to symptoms and clinical examination in transvaginal ultrasonography or diagnostic laparoscopy. 7-7-All women have a history of unexplained infertility 8-Normal ovulatory function and normal semen analysis according to the World Health Organization criteria .

Exclusion criteria

* Patients with other ovulation disorders such as hypo and hypergonadotropic, hypogonadism, hyperprolactinemia. 2-Thyroid disorders. 3-Ovarian or adrenal neoplasms. 4-Cushing syndrome. 5-previous history of systemic diseases such as endocrine and metabolic disorders. 6- Previous history of inappropriate ovarian response to stimulation with gonadotropins (poor responders). 7-Prior history of more than 3 unsucce

Design outcomes

Primary

Measure	Time frame	Description
fertility outcomes (pregnancy rate, abortion and live birth rate) in IVF patients.	5months	(pregnancy rate, abortion and live birth rate) in IVF patients.

Countries

Egypt

Contacts

Primary ContactAmna Abdel sabour

mannoon1991@gmail.com01092405752

Backup Contactkareem shaheen

01003957442

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026