Serum Biomarkers Associated With Postpartum T2DM in Women With GDM

Pregnancy to Postpartum Transition of Serum Biomarkers in Women With Gestational Diabetes

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT04539288

Enrollment

3099

Registered

2020-09-04

Start date

2013-05-01

Completion date

2018-05-30

Last updated

2020-09-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gestational Diabetes

Keywords

GDM, T2DM, NGT, lipids

Brief summary

Gestational diabetes mellitus (GDM) is commonly linked to the development of type 2 diabetes mellitus (T2DM). There is a need to characterize metabolic changes associated with GDM in order to find novel biomarkers for T2DM.

Detailed description

GDM, a common complication of pregnancy, affects 17.8% of pregnancies worldwide per year. Women with a history of GDM have an approximately 7-fold higher risk for developing T2DM in the future than women without GDM. However, data on the factors associated with the development of T2DM in women with GDM are not widely available.

Interventions

None listed

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Women who were dignosed GDM. * Women with singleton pregnancy. * Give birth in the First Affiliated Hospital in Sun Yat-sen University.

Exclusion criteria

* Women who were diagnosed PGDM. * Younger than 18 years old. * Older than 45 years old. * Multiple pregnancy. * Diagnosed DM before. * Complicationg other diseases, like hypertension, thyroid diseases, etc. * Taking any drug affect glucose and lipid metabolism.

Design outcomes

Primary

Measure	Time frame	Description
T2DM	4-6 weeks.	Women with GDM develop T2DM in postpartum.

Secondary

Measure	Time frame	Description
IGT	4-6 weeks.	Women with GDM were impaired glucose intolerance in postpartum.

Countries

China

Outcome results